Largest study of COVID-19 transmission highlights essential role of superspreaders

SINGAPORE – In the bleak ranking of worst COVID-19 outbreaks, the United States, with 7.2 million infections, is likely to be eclipsed only by India, which has 1 million fewer cases but is catching up fast.

Yet parts of India have led the world in one aspect of the pandemic response: contact tracing _ the labor-intensive, timesensitive, painstaking work of identifying people who were exposed to a known infected person.

Extensive contact tracing in two southern Indian states offers the strongest evidence yet that a few superspreading individuals are responsible for a disproportionate share of new coronavirus infections, according to a study published Wednesday in the journal

Science. It also suggests that children are more efficient transmitters of the virus than widely believed.

A team of Indian and

U.S. researchers examined data from 575,071 individuals who were tested after coming into contact with 84,965 people with confirmed cases of COVID-19. That’s an average of seven contacts per case, and a cohort more than 10 times larger than in a previous study from South Korea that mapped how the virus was transmitted.

“It’s the largest epidemiological study anywhere on COVID by far,” said the lead author, Ramanan Laxminarayan of the Center for Disease Dynamics, Economics and Policy, in New Delhi.

Laxminarayan and his colleagues found that just 8% of people with COVID-19 accounted for 60% of the new infections observed among the contacts. Meanwhile, 7 out of 10 COVID-19 patients were not linked to any new cases.

The finding underscores the essential role of superspreaders in the COVID-19 pandemic: One individual or event, such as in a poorly ventilated indoor space, can trigger a high number of new infections, while others might not transmit the virus at all.

In the new study, researchers tracked down 78 people who had shared a bus or train with one of eight known infected people and sat within three rows of that person for more than six hours. Health workers visited these contacts at their homes to conduct follow-up screenings and determined that nearly 80% of them had contracted the coronavirus.

By contrast, people who were known to be exposed to infected individuals in lower-risk environments – such as being in the same room but more than 3 feet away – became infected only 1.6% of the time.

“Superspreading events are the rule rather than the exception,” Laxminarayan said. “It has lots of implications for modeling COVID, for how to keep places safe.”

The study suggests that superspreading events are influenced by behavior _ that proximity to an infected person, length of contact and ambient conditions determine the level of risk. It doesn’t examine whether some infected people spread the virus more efficiently because of biological factors, a question scientists are still trying to answer.

The results could help guide safety measures in places such as gyms, churches and choir practice spaces that have been locations for previous superspreading events.

The study also found that although children younger than 17 were the least likely to die of COVID-19, they transmitted the virus at rates similar to the rest of the population, underscoring the idea that the disease doesn’t spare young people. One data point in particular holds implications for reopening schools: Children ages 5 to 17 passed the virus to 18% of close contacts their own age.

Antonio Salas, a

Spanish researcher who has investigated the role of superspreaders in the pandemic, said the study’s findings regarding children were important in light of “previous reports suggesting a minor role of children in the pandemic.”

“National policies on how to proceed with children in schools and other social activities could change dramatically if the scientific evidence underpins the idea that children can infect as efficiently as adults, and even more, they could also behave as superspreaders,” said Salas, who was not involved in the India study.

As India’s coronavirus caseload has doubled over the past month, from 3 million to more than 6 million, the study authors said their work showed one strength of the country’s response: the ability to mobilize large numbers of health workers and civil servants to conduct contact tracing, identify high-risk individuals and closely track their cases.