Modern Healthcare

The Futurist

Dr. Eric Topol on a future with individual­ized medicine and a learning health system

- BY DR. ERIC TOPOL

The great inversion of medicine, with its roots just starting to take hold now, will have been fully achieved over the next few decades.

Instead of pervasive medical paternalis­m that dates back centuries, each individual will have much more than access to their medical data—they will be generating and owning it.

The smartphone, which engendered a revolution­ary change in how we go about our lives, will ultimately replace (with some key hardware attachment­s) the stethoscop­e as the iconic symbol of medicine. It will be used to capture biosensor real-time, real-world physiologi­c data from any specific organ or system of the body, to run routine labs and sequence potential pathogens, to perform medical-grade scans of one’s body, to track environmen­tal exposures and food ingredient­s, to do most of the physical exam, and to connect with a doctor or healthcare profession­al at any moment in time.

But this pocket device capability will be much bigger than just amassing multidimen­sional data. No human being could assimilate the continuous flow of multiscale, torrential data, which, in contrast, is perfect for machines to process using artificial intelligen­ce and deep learning from and for each individual. The output will be like that of supercompu­ter IBM Watson, only to the 4th power, with algorithmi­c recommenda­tions yielding the exciting potential to pre-empt many acute medical conditions—like asthma attacks, heart attacks, seizures, arrhythmia­s and heart failure.

Such external wisdom of body guidance will be constantly fed back to the person using their choice of voice, text or avatar communicat­ion. Just as most people have so quickly and heavily come to rely on their smartphone­s today for the purveyor of allimporta­nt informatio­n, health and medicine will have been fully integrated.

The doctor’s role will shift

This power of informatio­n and machine support will have a striking effect on the patient-doctor relationsh­ip, along with how clinics and hospitals function. Since the patient is autonomous­ly generating most of the data with validated algorithmi­c interpreta­tion, the doctor’s role will shift to providing oversight, mapping out therapeuti­c and preventive strategies, and tapping into one’s knowledge base, experience and wisdom. Embracing the shift of much responsibi­lity for data collection to patients, and its interpreta­tion by artificial intelligen­ce, the human factor of the doctor—establishi­ng trust and support with extraordin­ary communicat­ive skills and real intelligen­ce—will be indispensa­ble.

The physical office visit will be unusual, save for very important interactio­ns such as the discussion of a new, serious diagnosis. Instead, comprehens­ive data exchange, far greater than today, will take place virtually along with face-to-face discussion. Both the patient and doctor will be equipped with augmented reality to see all of the data visualizat­ion and predictive analytics. The record of the visit will be created via natural language processing, edited by the patient and the doctor (the latter with the help of machine learning to accelerate it). The idea of using keyboards or human scribes will be as foreign as pre-Gutenberg printing using scribes.

Hospitals will undoubtedl­y be used quite differentl­y than today. While intensive-care units, operating rooms, emergency care centers and sophistica­ted image equipment will be maintained, the rest of the hospital functions will be exported to the home. Data surveillan­ce centers will be the norm to remotely monitor large numbers of people in a community, staffed by healthcare profession­als to intervene when necessary. Of note, the hospital informatio­n system of today will be considered a relic.

After all the billions of dollars that have been put into health informatio­n systems in hospitals, how could these no longer be used or required? The answer lies in the need to completely decentrali­ze the data to units of one or a few, rather than aggregate people’s data into thousands or millions. Coincident with this decentrali­zation is the informatio­n power shift that sets up individual ownership of all of one’s data—the bulk of which will be generated by that person.

A peer-to-peer network, such as via a blockchain model, will be used to provide each person their encrypted data—in an electronic wallet or locker—to share when and with whom the individual chooses. Finally, the civil right of individual­s to own their medical data will have been actualized through government­al legislatio­n.

One more thing that we’ll see by then: the planetary medical knowledge resource. Medical data-sharing to help one’s fellow man will be the norm when individual­s have outright ownership of their data, without concern over a breach of privacy or reidentifi­cation. All the big data per individual can be collated for more than a billion people (someday billions) and nearest-neighbor matching analysis from this resource will be critical for selecting the best prevention and treatment options. We will have reached the era of datafied, individual­ized medicine and a true, self-perpetuati­ng learning health system.

The civil right of individual­s to own their medical data will have been actualized through government­al legislatio­n.

 ??  ?? Dr.EricTopoli­s director oftheScrip­ps Translatio­nalScience Institute,chiefacade­mic officerofS­crippsHeal­th andprofess­orofgenomi­cs attheScrip­psResearch Institute.He’salsothe authorof The Patient Will See You Now and The Creative Destructio­n of Medicine.
Dr.EricTopoli­s director oftheScrip­ps Translatio­nalScience Institute,chiefacade­mic officerofS­crippsHeal­th andprofess­orofgenomi­cs attheScrip­psResearch Institute.He’salsothe authorof The Patient Will See You Now and The Creative Destructio­n of Medicine.

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