Monterey Herald

Seniors may need CBD, but how safe is it?

- By Daniele Piomelli UC Irvine Professor Daniele Piomelli teaches anatomy and neurobiolo­gy and is director of the Center for the Study of Cannabis.

For many of us, growing old means establishi­ng a close relationsh­ip with physical pain. Muscles ache. Joints creak. Arthritis flares up. If the pain becomes too great, your natural instinct is to seek solutions. Those might come from recommenda­tions, the internet or a local store.

There, you might hear about CBD — or cannabidio­l — which is derived from cannabis. Currently, there are a variety of CBD oils, gummies and supplement­s — and claims (thus far unsubstant­iated) that they can cure a wide range of maladies, including pain.

So, what’s the harm in trying CBD?

As an increasing number of older Americans are turning to CBD products for their health needs, we don’t know everything we need to about this substance, its health benefits and its potential ramificati­ons. What we do know is enough to raise concerns and to insist that barriers currently preventing essential research be removed.

The cannabis plant’s THC compound, which causes a “high,” has undergone extensive scientific study with thousands of research papers on the substance. The compound CBD, now in consumer products which could affect the well-being of millions of people, has received comparably little. Things have improved, research-wise, over the last five years but not to the extent one would expect for an increasing­ly popular substance marketed for its health benefits.

Unfortunat­ely, there aren’t many incentives for researcher­s to study cannabis because unregulate­d products are widely available and many bureaucrat­ic barriers exist. Thus, there are few published papers on the physical impact of different CBD formulatio­ns.

We do know that there are potential therapeuti­c benefits of CBD. Of the research that has occurred, a significan­t portion documents how CBD can help treat seizures associated with rare forms of childhood epilepsy. There are also significan­t studies from Germany and Brazil that have investigat­ed whether CBD can help patients with serious mental disorders like anxiety and schizophre­nia.

One critical area in which we don’t have sufficient knowledge is dosage. CBD products are usually consumed in high doses that are eliminated from the body by the liver. Seniors tend to take more medication­s, some critically important, than younger people. A person taking many medicines that need to be metabolize­d is overworkin­g their liver, making that organ incapable of handling all the assignment­s sent its way. Thus, a high dose of CBD could potentiall­y dilute lifesaving drugs or, vice versa, could cause a drug to accumulate at dangerous levels.

We also don’t have enough data on the potential side effects of CBD. If your grandmothe­r takes a CBD supplement and begins suffering confusion or memory loss, is it a result of the CBD or the early stages of Alzheimer’s? We don’t have enough research to draw meaningful conclusion­s.

We need to be able to optimize the positive role of CBD in meeting health needs. But we must compile enough data and evidence to understand how to avoid negative complicati­ons. The FDA approval process can play a critical role, ensuring that thorough research, randomized clinical trials and significan­t data are used to bring safe and effective CBD treatments to market.

But the FDA can’t do this unless we remove barriers to research. Congress must reduce the efforts necessary to launch research studies and encourage more scientists and academic medical centers to devote time and resources to the subject.

Our seniors have seen enough health risk in the past year. Let’s not put them in greater potential danger by exposing them to untested products.

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