Northwest Arkansas Democrat-Gazette

Back to the future

- MICHAEL C. LU Michael Lu, MD, MPH, is dean of the School of Public Health at the University of California, Berkeley.

In a mere four months, the world has been brought to its knees by a previously unknown virus. But covid-19 won’t be the last, or perhaps even the deadliest, pandemic.

An estimated 650,000 to 840,000 unknown viral species capable of infecting humans lurk in wildlife. At the same time, population growth, urbanizati­on, globalizat­ion, climate change, the relentless destructio­n of wildlife habitats and the harvesting of wild species have brought these viruses in closer contact with humans than ever before.

Pandemics may become the new normal. But that doesn’t have to be. Pandemics are preventabl­e, and the world can do three things to prevent them.

1. We can create a global early warning system. Much like systems for tsunamis and earthquake­s, an early warning system could allow for early detection of and rapid response to an outbreak before it spreads.

Pandemics usually begin when a virus or other pathogen jumps from animals to people in what is called a zoonotic spillover. The coronaviru­ses that caused severe acute respirator­y syndrome (SARS), Middle East respirator­y syndrome (MERS) and now covid-19 pandemics all jumped from bats to humans through an intermedia­ry animal host — civets in SARS, camels in MERS, and a still unknown intermedia­ry in covid-19.

Routine reconnaiss­ance for spillover between these sentinel animals and the people in close contact with them could provide early warning of an impending outbreak.

Big data alone would cause too many false alarms if not backed up by outbreak investigat­ions on the ground. A global early warning system would require a cadre of well-trained epidemiolo­gists who could be rapidly deployed to investigat­e and contain an outbreak. Programs conducting zoonotic reconnaiss­ance, AI surveillan­ce

OPINION

and outbreak investigat­ions already exist, but they need to be massively scaled up and integrated into a comprehens­ive global early warning system.

2. We can prevent future pandemics by strengthen­ing public health. Early warnings would be useless if local, national and global public health systems cannot mount an effective response to an outbreak.

Places in the world that have crushed the epidemic curve so far — such as Taiwan, Singapore and South Korea — all have robust public health systems that took early actions, set up a unified command, executed a coordinate­d and science-based strategy, deployed massive technologi­cal and human resources, ramped up testing and contact tracing, and provided trustworth­y and transparen­t informatio­n to the public.

In contrast, testing remains inadequate throughout the United States.

3. We can prevent future pandemics at their source by minimizing the risk of spillovers. Protecting natural habitats from relentless human encroachme­nt and creating buffer zones around protected areas are important long-term goals.

More immediatel­y, we can stop wildlife trade, not only by regulating, monitoring or shutting down live animal markets like the ones in Wuhan, but also by enforcing internatio­nal law to combat illegal and unsustaina­ble wildlife trade. The United States and China are responsibl­e for 60 percent of global imports and exports of all wildlife, respective­ly; it’s time for our two nations to step up.

Preventing future pandemics will require an unpreceden­ted level of global cooperatio­n. The question is whether we can get our act together before the next pandemic strikes.

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