Treating of virus work in progress

Early on, physicians at a loss

Amid the chaos of the pandemic’s early days, doctors who faced the first coronavirus onslaught reached across oceans and language barriers to advise colleagues trying to save lives in the dark.

With no playbook to follow and no time to wait for research, YouTube videos describing autopsy findings and X-rays swapped on Twitter and WhatsApp spontaneously filled the gap.

When Stephen Donelson arrived at the University of Texas Southwestern Medical Center in mid-March, Dr. Kristina Goff was among those who turned to what she called “the stories out of other places that were hit before.”

Donelson’s family hadn’t left the house for two weeks after covid-19 started spreading in Texas, hoping to protect Donelson, an organ transplant recipient. Yet one night, his wife found him barely breathing, his skin turning blue, and called 911.

In the overflowing hospitals in New York or Italy, Goff thinks Donelson wouldn’t even have qualified for a then-precious ventilator. But in Dallas, “we pretty much threw everything we could at him,” she said.

STEEP LEARNING CURVE

Like doctors everywhere, Goff was at the beginning of a huge learning curve.

“It’s a tsunami. Something that if you don’t experience it directly, you can’t understand,” Italian Dr. Pier Giorgio Villani said in the first of a series of webinars organized to alert other intensive care units what to expect — just two weeks after Italy’s first hospitalized patient arrived in his ICU, and 10 days before Donelson fell ill in Texas.

The video sessions, organized by an Italian association of ICUs, GiViTI, and the nonprofit Mario Negri Institute and later posted on YouTube, constitute an oral history of Italy’s outbreak as it unfolded, narrated by the first doctors in Europe to fight the coronavirus.

Italian friends spread the word to doctors abroad, and translations began for colleagues in Spain, France, Russia and the U.S., all bracing their own ICUs for a flood of patients.

They offered “a privileged window into the future,” said Dr. Diego Casali of Cedars-Sinai Medical Center in Los Angeles, who was directed to the webinars when he sought advice from an Italian front-line friend about how to prepare.

Every tidbit about the newest baffling symptom, every trick to try, served as clues as the virus bore down on the next city, the next country. By the time Donelson arrived, Goff’s hospital was adjusting ventilator care based on that early advice.

But while grateful for the global swirl of information, Goff also struggled to make sense of conflicting experiences.

“You have no idea how to interpret what went right or what went wrong,” she said, “or was it just the native course of the disease?”

CONFUSING TIME

Doctors in Italy were confused: Reports from China were suggesting a death rate of about 3% among those infected. But for the first 18 days, only dead people left the ICU at Bergamo’s Pope John XXIII Hospital.

While the toll eventually dropped, 30% of the hospital’s initial 510 covid-19 patients died.

After decades in practice, ICU chief Dr. Luca Lorini thought he knew how to treat the dangerous kind of respiratory failure — called ARDS, or acute respiratory distress syndrome — first thought to be the main threat.

“Every night, I would go home and I had the doubt that I had gotten something wrong,” Lorini said. “Try to imagine: I am all alone, and I can’t compare it with France because the virus wasn’t there, or Spain or the U.K. or America, or with anyone who is closer to me than China.”

By February, China had filed only a limited number of medical journal reports on how patients were faring. Lorini’s hospital tried to fill the gap by dividing patients into small groups to receive different forms of supportive care and comparing them — not a scientific study, but some real-time information to share.

The first lessons: The coronavirus wasn’t causing typical ARDS, and patients consequently needed gentler ventilation than normal, for longer than usual.

Mid-March brought a startling surprise: In a training video for U.S. cardiologists, Chinese doctors warned that the virus causes dangerous blood clots, and not just in the lungs. They urged American doctors to use blood thinners protectively in the severely ill.

“We’re learning as we go,” said Dr. Tiffany Osborn, a critical care physician at Washington University School of Medicine in St. Louis. “You could talk to me in two weeks, and I might be telling you something that’s really different.”

A NEW SKILL

When Donelson arrived in the Dallas hospital, “we had very little hope for him,” Goff said. He was battling against the ventilator’s artificial breaths, so Goff deeply sedated him to let the machine do all the work.

Hospital after hospital had struggled with balancing how to get enough air into oxygen-starved coronavirus patients without further damaging fragile lungs. One procedure that helped is proning — turning patients from their backs to their stomachs in a prone position to take pressure off the lungs.

Donelson stayed on his belly about 16 hours a day early on, as his doctors watched his oxygen levels improve.

Hospitals that specialize in treating ARDS knew how to prone before covid-19 hit. For many others, it was a brandnew skill.

“We’ve never had to prone anyone here before the pandemic, but now it’s like second nature,” said Kevin Cole, a respiratory therapist at Maryland’s Fort Washington Medical Center.

Information for this article was contributed by Nathan Ellgren of The Associated Press.