First person cured of HIV infection has terminal cancer
Timothy Ray Brown, the first person known to have been cured of HIV infection, says he is now terminally ill from a recurrence of the cancer that prompted his historic treatment 12 years ago.
Brown, dubbed “the Berlin patient” because of where he lived at the time, had a transplant from a donor with a rare, natural resistance to the AIDS virus.
For years, that was thought to have cured his leukemia and his HIV infection, and he still shows no signs of HIV.
But in an interview, Brown said his cancer returned last year and has spread widely. He’s in hospice care in Palm Springs, California.
“I’m still glad that I had it,” Brown said of his transplant.
“It opened up doors that weren’t there before” and inspired scientists to work harder to find a cure, which many had begun to think was not possible, the 54year-old said this week.
“Timothy proved that HIV can be cured, but that’s not what inspires me about him,” said Dr. Steven Deeks, an AIDS specialist at the University of California, San Francisco, who has worked with Brown to further research toward a cure.
“We took pieces of his gut, we took pieces of his lymph nodes. Every time he was asked to do something, he showed up with amazing grace,” Deeks said.
Brown was an American working as a translator in Berlin in the 1990s when he learned he had HIV. In 2006, he was diagnosed with leukemia.
Dr. Gero Huetter, a blood cancer expert at the University of Berlin, believed that a marrow transplant was Brown’s best chance of beating the leukemia. He wondered, could he also cure Brown’s other lifethreatening disease by using a donor with a gene mutation that provides natural resistance to the AIDS virus?
Donors like these are very rare and transplants are risky. Doctors have to destroy the patient’s diseased immune system with chemotherapy and radiation, then transplant the donor’s cells and hope they develop into a new immune system for the recipient.
Brown’s first transplant in 2007 was only partly successful: His HIV seemed to be gone but his leukemia was not. He had a second transplant from the same donor in March 2008 and that one seemed to work.