Wild weather
The Martian climate sucks, look out for these
Dust
Mars is very dusty. That’s a problem for solar panels and anyone with serious allergies. It can’t be avoided, but not building dust-spewing mines near other buildings helps.
Tornados
Martian tornados wreck everything in their path, and they always seem to find a way to take out the life support. All you can do, really, is get the hell out of the way.
Meteorshowers
Even the sky hates you. Early warning systems can be unlocked, and even automated lasers, but until then, you’ll just have to hope a rock doesn’t strike one of your domes.
Thecold
Some areas get so cold that domes can’t properly protect the colonists. Heaters can keep everyone toasty, though that means you’ll need to put stress on your power supply.