Pittsburgh Post-Gazette

Another ‘unfounded’ study on origins of virus spreads online

- By Katherine J. Wu

An overwhelmi­ng body of evidence continues to affirm that the coronaviru­s almost certainly made its hop into humans from an animal source — as many, many other deadly viruses are known to do.

But since the early days of the pandemic, experts have had to fight to combat misinforme­d rumors that the coronaviru­s emerged from a lab as part of a sinister scientific project.

Last week, yet another piece of unfounded and misleading prose entered the fray: a study, posted online but not published in a peer-reviewed scientific journal, contending the virus is artificial and an “unrestrict­ed bio-weapon” released by Chinese researcher­s.

The manuscript also baselessly denounced several parties, including policymake­rs, scientific journals and even individual researcher­s, for censoring and criticizin­g the lab-made hypothesis, accusing them of deliberate obfuscatio­n of fact and “colluding” with the Chinese Communist Party.

Though scientists immediatel­y condemned the study as disreputab­le and dangerous, it rapidly commanded a storm of social media attention, garnering more than 14,000 likes on Twitter and more than 12,000 retweets and quote-tweets within days of its posting. Shared on Facebook, Twitter and Reddit, it reached millions of users and was covered in at least a dozen articles written in several languages.

The paper’s findings, however, have no basis in science.

“It’s ridiculous and unfounded,” said Angela Rasmussen, a virologist at Columbia University who criticized the study on Twitter the day it was released. “It’s masqueradi­ng as scientific evidence, but really it’s just a dumpster fire.”

The publicatio­n is the second in a series from a team led by Li-Meng Yan, a Chinese scientist who released an initial paper on Sept. 14, also not peer-reviewed, asserting the coronaviru­s was synthetic. Dr. Yan’s background is a little murky. She left her position as a postdoctor­al research fellow at Hong Kong University for undisclose­d reasons some time ago, according to a July statement from the institutio­n, and fled to the United States. Both papers list Dr. Yan and her co-authors as affiliated with the Rule of Law Society, a nonprofit whose founders include Steve Bannon, a former White House chief strategist, who has since been charged in an unrelated case of fraud.

“That alone should give people pause,” Dr. Rasmussen said of the team’s connection to Mr. Bannon’s nonprofit.

Dr. Yan and her colleagues did not respond to a request for comment.

Their original paper — known as “the Yan report” — was also seized upon by thousands online and reported on in the New York Post, even though experts rapidly debunked its findings. Researcher­s called it unscientif­ic and said it ignored the wealth of data pointing to the virus’s natural origins.

Close relatives of the new coronaviru­s exist in bats. The virus may have moved directly into people from bats or first jumped into another animal, such as a pangolin, before transition­ing into humans. Both scenarios have played out before with other pathogens.

“We have a very good picture of how a virus of this kind could circulate and spill over into human beings,” said Brandon Ogbunu, a disease ecologist at Yale University.

It may take quite some time to pinpoint exactly which animals harbored the virus along this chain of transmissi­on, if scientists ever do at all — inevitably leaving some parts of the virus’s origin story ambiguous. Like many other conspiracy theories, the labmade hypothesis “exploits the open questions in an ongoing investigat­ion,” Dr. Ogbunu said.

But there is no evidence so far to support a synthetic source for the virus.

Dr. Yan’s Twitter account was suspended in September 2020 for pushing coronaviru­s disinforma­tion. She shared the “second Yan report” from a second Twitter account, which has gained more than 34,000 followers.

Together, the papers written by Dr. Yan and her colleagues lay out what they identified as abnormalit­ies in the genome sequence of the coronaviru­s. They suggested those unusual features indicated the virus’s genome had been purposeful­ly spliced togetheran­d modified, using the genetic material from other viruses, Dr. Yan told Fox News in September. The cousins of the coronaviru­s that had been identified in bats, they said, were also fake, human-made constructi­ons, thus supposedly quashing the naturalori­gin hypothesis.

The authors also contended the coronaviru­s’s genome had been manipulate­d by scientists.

But outside experts have found no validity in either Yan report. The first was “full of contradict­ory statements and unsound interpreta­tions” of genetic data from viruses, said Kishana Taylor, a virologist at Carnegie Mellon University.

And the second Yan report “was even more unhinged than the first,” said Gigi Kwik Gronvall, a senior scholar at the Johns Hopkins Center for Health Security and an author of a response debunking the original Yan report.

The supposedly strange features found in the genomes of the coronaviru­s and its natural relatives aren’t actually red flags at all, Dr. Ogbunu said. Viruses frequently move between animal hosts, changing their genetic material along the way — sometimes even swapping hunks of their genomes with other viruses. And many of the purported abnormalit­ies in the coronaviru­s are found in other virus genomes.

The notion the coronaviru­s was “designed” to be dangerous is also “just nonsense,” Dr. Ogbunu said. Scientists don’t know enough about viruses to predict which mutations would increase their lethality, let alone engineer these changes into new pathogens in the lab.

Building the coronaviru­s from such a mishmash of genetic templates, as described by Dr. Yan and her colleagues, would also raise herculean logistical hurdles for even the most dogged scientists.

Part of this process would require researcher­s to laboriousl­y tinker with thousands of individual letters in the alphabet soup that is a virus’s genome — an absurdly inefficien­t scientific strategy, Dr. Rasmussen said.

“Extraordin­ary claims require extraordin­ary evidence,” Dr. Rasmussen said. “And this is not that.”

 ?? Nicolas AsfouriI/AFP via Getty Images ?? People wearing face masks as a preventive measure against COVID-19 commute during rush hour Tuesday on a street outside of a shopping mall complex in Beijing.
Nicolas AsfouriI/AFP via Getty Images People wearing face masks as a preventive measure against COVID-19 commute during rush hour Tuesday on a street outside of a shopping mall complex in Beijing.

Newspapers in English

Newspapers from United States