Jay Cutler had 213 yards passing with two touchdowns and one interception for the Dolphins (4-5), who have lost three straight.
The game turned with 41 seconds left in the first half, when Luke Kuechly intercepted Jay Cutler with Carolina leading 10-7.
Four plays later, Newton connected with Ed Dickson on a 7-yard touchdown pass. That opened the floodgates as the Panthers scored touchdowns on five straight drives.
The Panthers gave Mccaffrey the start at running back over Stewart, who fumbled twice last week against the Falcons. Mccaffrey didn’t let them down, combining for 50 yards and two scores,
including a nifty 4-yard touchdown run where he faked out two Miami defenders.
Dolphins safety T.J. Mcdonald returned to the starting lineup after serving an eight-game suspension for violating the league’s substance abuse policy, but it didn’t help the struggling Dolphins defense.
Kenyan Drake provided the big play for the Dolphins, breaking free for a 66-yard touchdown run in the third quarter.
Newton passes Dan Marino for the thirdmost total yards (passing and rushing) in a quarterback’s first seven seasons. Newton trails only Peyton Manning and Matt Ryan in that category.