49ers 25, Titans 23

SANTA CLARA, Calif. — Jimmy Garoppolo led one final scoring drive in the closing seconds to cap a fantastic first home start and Robbie Gould kicked a winning 45-yard field goal as time expired.

Garoppolo threw for a careerhigh 381 yards and a touchdown to give the 49ers (4-10) a three-game winning streak in a lost season. And Tom Brady’s former backup showed he could do it at home as well as on the road — and against a playoff contender, no less — outdueling Marcus Mariota down the stretch as the teams traded field goals.

Jacksonville wide receiver Keelan Cole (84) is tackled by Houston Texans cornerback Johnathan Joseph (24) during the first half of Sunday’s game in Jacksonville, Fla.

season-high 434-yard passing game by Eli Manning.

Foles hit Alshon Jeffery, Zach Ertz, Trey Burton and Nelson Agholor on scoring passes ranging from 3 to 13 yards in filling in for Wentz, who tore an ACL last week and was lost for the season after a brilliant year.

The Eagles also got two field goals from Jake Elliott and three blocked kicks from their special teams, foiling an extra point, a punt and field goal. The block on the punt set up a touchdown.

Manning finished 37 of 57 and hit Tavarres King on two touchdowns and Sterling Shepard on one. It was Manning’s ninth career 400yard game and his first since last season.

The Browns are two losses from becoming the NFL’s second 0-16 team. Stephen B. Morton / AP