San Antonio Express-News

» Merck abandons 2 vaccines in clinical trials.

- By Carl Zimmer

Merck announced Monday that it was abandoning a pair of COVID-19 vaccines in clinical trials.

The news came as a disappoint­ment at a time when the United States and other countries are struggling to accelerate their sluggish vaccinatio­n campaigns and new coronaviru­s variants threaten to bring surges over the next few months.

The two projects are the second and third vaccines to be abandoned in clinical trials. The University of Queensland in Australia abandoned its own effort in December. Sanofi and other vaccine-makers have paused some projects after getting disappoint­ing initial results but are now regrouping to move forward.

Researcher­s began a Phase 1 trial in August. In a second effort, Merck partnered with IAVI, a nonprofit scientific organizati­on that develops vaccines and treatments, on another vaccine.

Merck will instead focus its COVID-19 efforts on an experiment­al antiviral drug known as molnupirav­ir. Originally designed for influenza, it has shown promising effects in studies on animals and in early clinical trials. The trial is set to finish by May, although preliminar­y results could come out as early as March.

IAVI said it would continue searching for COVID-19 vaccines.

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