San Diego Union-Tribune

SOUTH AFRICA IDENTIFIES NEW VARIANT OF CORONAVIRU­S

Mutations show ‘big jump in evolution,’ epidemiolo­gists say

- BY LYNSEY CHUTEL & ANDRÉS R. MARTÍNEZ Chutel and Martínez write for The New York Times.

Scientists in South Africa identified on Thursday a concerning new variant of the coronaviru­s, whose mutations mark a “big jump in evolution” that is driving a spike in new cases. Hours later, Britain banned flights from six southern African nations citing the variant.

In the past two days, scientists detected the B1.1.529 variant after observing an increase in infections in South Africa’s economic hub surroundin­g Johannesbu­rg. So far, 22 positive cases have been identified in the country, according to South Africa’s National Institute for Communicab­le Diseases. One case has been detected in Hong Kong from someone who had traveled from South Africa. No cases have been detected yet in Britain.

Since the onset of the pandemic, a number of variants have emerged. One underlying concern about new variants is whether they will stymie progress against the pandemic or whether they will limit the effectiven­ess of vaccines. South African scientists will meet with the World Health Organizati­on technical team today, where authoritie­s will assign a letter of the Greek alphabet to this variant.

By Thursday evening, Britain had banned flights from South Africa, Botwsana, Eswatini, Lesotho, Namibia and Zimbabwe starting at noon local time today. The six nations will be added to the country’s red list, which would require British travelers coming from those nations to quarantine on arrival.

In December 2020, South Africa was the first nation to report the appearance of the beta variant, which has now spread to nearly 70 countries. Scientists have been concerned that some clinical trials have shown that vaccines offer less protection against the Beta variant. Since then, the more virulent and aggressive Delta variant has spread all over the world and is believed to be fueling the latest surge in cases.

Britain had only just weeks ago announced that it would stop requiring any travelers to quarantine in government-designated hotels, removing the last seven countries from its “red list” for coronaviru­s risk. Instead, now, government­s across Europe are moving to shore up the progress made against the pandemic that is being threatened by the latest wave of new cases.

The variant has also been identified in Botswana. The country’s health ministry confirmed in a statement that four cases of the new variant were detected in people who were all fully vaccinated. All four were tested before their planned travel.

With over 1,200 new infections, South Africa’s daily infection rate is much lower than in Germany, where new cases are driving a wave. However, the density of mutations on this new variant raises fears that it could be highly contagious, leading scientists to sound the alarm.

“This variant did surprise us, it has a big jump in evolution, many more mutations than we expected, especially after a very severe third wave of Delta,” said Tulio de Oliveira, director of the KwaZulu-Natal Research and Innovation Sequencing Platform.

The B1.1.529 variant has a “very unusual constellat­ion of mutations,” with more than 30 mutations in the spike protein alone, said de Oliveira. On the ACE2 receptor — the protein that helps to create an entry point for the coronaviru­s to infect human cells — the new variant has 10 mutations. In comparison, the Beta variant has three, the Delta variant has two, said de Oliveira.

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