49ers ( 3- 3) at Patriots ( 2- 3)

When: 1: 25 p. m., 5 # z ( 104.5, 680, 107.7)

Spotlight on: FS Tarvarius Moore: Moore is the most surprising member of The Replacements, the group of players in prominent roles because of injuries to seven season- opening starters. Moore became Sunday’s starter when Jimmie Ward was injured in Thursday’s practice. The 2018 third- round pick will be making his first start since he made the last of three uneven season- opening starts in place of Ward last year. The 49ers allowed three receptions of 50- plus yards last season, and Moore took poor angles on two of them: a 76- yard TD by Pittsburgh’s JuJu Smith- Schuster in Week 3 and a 66yard score by Cincinnati’s John Ross in Week 2.

Injury notes: 49ers — LB Kwon Alexander ( ankle), FS Jimmie Ward ( quadriceps) and SS Jaquiski Tartt ( groin) are out; RB Jeff Wilson ( calf) and S Marcell Harris ( ankle) are questionable. Patriots — S Kyle Dugger ( ankle), WR Julian Edelman ( knee), G Shaquille Mason ( calf) and DE Derek Rivers ( back) are questionable.

THREE THINGS TO WATCH

Patriots QB Cam Newton has a 63.3 passer rating in his past two starts. Newton has completed 34 of 53 passes for 319 yards with a TD and three INTs. Newton has a team- high 225 rushing yards, which is 83 more than Rex Burkhead, who has the second most yards among players on New England’s active roster. 49ers CB Jason Verrett, who will be making his fifth start, has allowed five completions on 15 targets for 28 yards and has an interception. QBs have a 14.6 rating when targeting Verrett.