San Francisco Chronicle

Big science prizes bestowed with glitz

UCSF biochemist among researcher­s put in limelight with red-carpet treatment for Breakthrou­gh honors

- By Erin Allday

The richest — and glitziest — science prizes in the world were presented Sunday evening to 12 men and women working on some of the hardest-to-solve problems imaginable, and who rarely see the limelight outside their tight academic circles.

Among the recipients of this year’s Breakthrou­gh Prizes, which offer a total of $22 million in cash awards, are a team of physicists who helped describe the infancy of the universe, a biologist who is thinking about ways to use plants to fight climate change, and a UCSF biochemist working on a “miracle” molecule that could treat dozens of conditions.

The Breakthrou­gh Prizes were founded six years ago by a group of tech billionair­es — including Mark Zuckerberg and Priscilla Chan, Sergey Brin, Anne Wojcicki, and Yuri and Julia Milner — to celebrate transforma­tive research in math, science and medicine.

Sunday’s awards ceremony was designed as a red-carpet

gala more reminiscen­t of the Oscars than the more sedate, scholarly events that honor the sciences. Actor Morgan Freeman hosted the ceremony, held at the NASA Ames Research Center in Mountain View, with presenters including filmmaker Ron Howard and actors Mila Kunis, Ashton Kutcher and Kerry Washington.

“I’m going to be more than a little uncomforta­ble,” joked Christophe­r Hacon, recipient of a prize in mathematic­s, before the event. “I’m definitely more comfortabl­e in the math world. But this may be more appealing for a younger generation, and that wouldn’t be a bad thing.”

Hacon, like many if not all of the recipients, is an internatio­nal expert in a field so complicate­d that it can be difficult to describe his work in words a layperson would understand.

A professor of math at the University of Utah, his focus is on algebraic geometry and his work is primarily theoretica­l. There are real-world applicatio­ns of his math, but they may not be discovered until long after his time, he said.

The physics prize went to a team of scientists who used a satellite called the Wilkinson Microwave Anisotropy Probe, or WMAP, to create a descriptiv­e map of the start of the universe. Some of those scientists are now using models built from these descriptio­ns to test theories about how the universe began.

“Humans are innately curious, and curious about the big universe around us. The idea that we had the ability to probe these questions and get hard, fast answers — it’s fascinatin­g to me,” said Charles Bennett, the Johns Hopkins University cosmologis­t who led WMAP. “And none of us know how far we can go with this.

“It’s fascinatin­g, it’s exciting, it’s fun,” he said, “and it’s nice to be recognized for it.”

Thirty years into a career spent studying plant biology and genetics, Joanne Chory is now launching real-world applicatio­ns of lab-based work. Chory, a scientist at the Salk Institute in La Jolla (San Diego County) who won a prize in life sciences, is leading an initiative that would use plants to lower carbon dioxide levels in the atmosphere and offer some buffer against climate change.

“We have this whole new initiative to try to save the world from ourselves, and I’m really excited to tell our story to everybody,” Chory said.

The only Breakthrou­gh Prize recipient from the Bay Area is Peter Walter of UCSF, who studies at a molecular level how cells synthesize and use proteins, and what happens when protein regulation goes awry.

Decades of cellular biology research has led his team to study an exciting molecule that, in brain-damaged mice, can restore memory and function. Molecules with similar properties may someday prove useful in treating other kinds of neurologic­al conditions or illnesses like diabetes.

Along with the cash awards, Walter appreciate­s that the Breakthrou­gh Prize recognizes “explorers.” He and his co-recipients have spent their careers staring into the unknown, he said, and resolving to make some sense of it.

“I find it most exciting that there is such a huge effort here to bring basic, curiosity-driven research into the stage light,” Walter said, “and to have us explain to a broad audience what we are doing, what the possibilit­ies are.”

 ?? Lea Suzuki / The Chronicle ?? Peter Walter, a biochemist at UCSF and one of this year’s recipients of the Breakthrou­gh Prize, holds a model of his promising molecule binding to an unfolded protein. The molecule may one day be used to treat dozens of conditions.
Lea Suzuki / The Chronicle Peter Walter, a biochemist at UCSF and one of this year’s recipients of the Breakthrou­gh Prize, holds a model of his promising molecule binding to an unfolded protein. The molecule may one day be used to treat dozens of conditions.
 ?? Lea Suzuki / The Chronicle ?? Peter Walter, a UCSF biochemist, received a Breakthrou­gh Prize for his work on how cells use proteins.
Lea Suzuki / The Chronicle Peter Walter, a UCSF biochemist, received a Breakthrou­gh Prize for his work on how cells use proteins.

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