San Francisco Chronicle

Creator of opioids to cease marketing

- By Marley Jay and Matt Perrone Marley Jay and Matt Perrone are Associated Press writers.

NEW YORK — The maker of the powerful painkiller OxyContin said it will stop marketing opioid drugs to doctors, bowing to a key demand of lawsuits that blame the company for helping trigger the current drug abuse epidemic.

OxyContin has long been the world’s top-selling opioid painkiller, bringing in billions in sales for privately held Purdue, which also sells a newer and longer-lasting opioid drug called Hysingla.

The company announced its surprise reversal Saturday. Purdue’s statement said it eliminated more than half its sales staff last week and will no longer send sales representa­tives to doctors’ offices to discuss opioid drugs. Its remaining sales staff of about 200 will focus on other medication­s.

The OxyContin pill, a timereleas­e version of oxycodone, was hailed as a breakthrou­gh for chronic pain when approved in late 1995. It worked over 12 hours to maintain a steady level of oxycodone in patients suffering from a wide range of pain ailments. But some users quickly discovered they could get a heroin-like high by crushing the pills and snorting or injecting the entire dose at once. In 2010 Purdue reformulat­ed OxyContin to make it harder to crush.

Purdue eventually acknowledg­ed that its promotions exaggerate­d the drug’s safety and minimized the risks of addiction. After federal investigat­ions, the company and three executives pleaded guilty in 2007 and agreed to pay more than $600 million for misleading the public about the risks of OxyContin. But the drug continued to rack up blockbuste­r sales.

U.S. deaths linked to opioids have quadrupled since 2000 to roughly 42,000 in 2016.

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