San Francisco Chronicle

DNA maker Twist plans to go public

- By Catherine Ho

Twist Bioscience, the San Francisco startup that makes synthetic DNA used in geneticall­y modified foods and pharmaceut­ical drugs, is the latest Bay Area biotech firm gearing up to go public.

The company, founded in 2013 and based in the city’s Mission Bay neighborho­od, on Tuesday filed a form S-1 saying it plans to raise up to $86.3 million in an initial public offering.

Twist manufactur­es “made-to-order” DNA in its lab and sells it to pharmaceut­ical companies, research institutio­ns and government health agencies. The DNA is used to test cancer treatments and detect pathogens in blood, among other things.

The company reported $10.8 million in revenue in 2017 — up 375 percent compared to $2.3 million in 2016, according to the filing. It is on track to expand further, having reported $17 million in revenue for the first nine months of

2018.

In the filing, the company acknowledg­es a pending lawsuit against Twist CEO Emily Leproust could be a liability. The suit, filed by Leproust’s former employer Agilent, accuses Leproust of stealing trade secrets from Agilent to start Twist.

“An adverse result could harm our business and results of operations,” the company says in the filing.

A Twist spokeswoma­n declined to comment. Leproust’s attorneys have previously described the lawsuit an attempt to “stifle the innovative work of a burgeoning startup company,” and said that Twist’s other co-founders were responsibl­e for developing the critical technology that led to Twist.

Other local biotech companies that have recently gone public, or announced intentions to do so, include Hayward’s Arcus Bioscience­s and Emeryville’s Gritstone Oncology.

 ?? Santiago Mejia / The Chronicle ?? Twist Bioscience CEO Emily Leproust is being sued by Agilent, her former employer. The suit accuses her of stealing trade secrets.
Santiago Mejia / The Chronicle Twist Bioscience CEO Emily Leproust is being sued by Agilent, her former employer. The suit accuses her of stealing trade secrets.

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