◆ Will defenses play a roll in the Vikings-Seahawks matchup?

Here is a look at NFL Week 5, with all picks made against the point spread.

Last week’s record: 7-7-1 Overall record: 34-28-1

Bye weeks: Lions, Packers

BROADCAST LOCALLY Raiders at Chiefs

11 a.m. CBS

Line: Chiefs -13 | Total: 56

The Chiefs (4-0) are starting to feel like a team capable of beating the best teams with ease, but one that often shows a lack of concentration and urgency when playing against lesser competition. Needing overtime to beat the Los Angeles Chargers was bad enough, but playing three quarters of totally uninspired football against the decimated New England Patriots in Week 4 — the score was 6-3 at halftime, and 13-3 after three quarters — was even worse. The offense did finally wake up, cruising to a 26-10 win, but if the Chiefs are not going to take the entire game seriously, making them two-touchdown favorites against the Raiders (2-2) doesn’t seem right.

Pick: Raiders +13

Eagles at Steelers

11 a.m. Fox

Line: Steelers -7 | Total: 44

The Steelers (3-0) are playing at home with an extra week of rest (as a result of their Week 4 game against Tennessee being delayed) against the Eagles (1-2-1), who despite being the nominal division leaders in the NFC East are beat up and wildly inconsistent. Despite everything, Philadelphia’s defense has played above average and the team shouldn’t get blown out too often. But this doesn’t seem like it will be a pretty week for them, and their reign as a division leader should be short-lived.

Pick: Steelers -7

Giants at Cowboys

2:25 p.m. CBS

Line: Cowboys -9.5 | Total: 54

In his past three games, Dak Prescott of the Cowboys (1-3) has thrown for 450, 472 and 502 yards. It’s an unprecedented run of 450-yard games, and the only thing stopping him from getting to four is the likelihood that Dallas will get off to a big lead against the Giants (0-4) and will not need to keep throwing. The point spread is a little aggressive, and the Giants made Las Vegas look foolish last week by playing the Los Angeles Rams much closer than predicted, but Prescott might want to prove a point against a division rival.

Pick: Cowboys -9.5

Vikings at Seahawks

6:20 p.m. NBC

Line: Seahawks -7 | Total: 57 Oddsmakers have predicted this to be the week’s highest scoring game. The Vikings (1-3), with a multipronged offensive attack, led by Kirk Cousins, Dalvin Cook, Adam Thielen and Justin Jefferson, have averaged 26.5 points a game — topping 30 points in three of their four outings — and the Seahawks (4-0) are in the midst of what looks like an MVP season from Russell Wilson, who has Seattle averaging 35.5 points a game.

Add in the fact that both teams’ defenses have at best been marked “present,” and that Seattle potentially will be without safety Jamal Adams, cornerback Quinton Dunbar and linebacker Jordyn Brooks, this one might be a matchup in which the winner is the first team to 50.

There will be no fans, so Seattle’s typical noise advantage won’t be an issue. And while Wilson should be expected to win against just about anyone, there is every reason to believe that Minnesota can score enough to make this a close game.

Pick: Vikings +7

Broncos at Patriots

3 p.m. Monday ESPN

Line: Off | Total: Off

One might have envisioned this as a game to watch when the schedule was made. Drew Lock, a plucky sophomore quarterback for the Broncos (1-3), going into Foxborough, Mass., for the first time to face the hardcharging Patriots (2-2), who had been remade by Cam Newton. Instead, Lock is out with a shoulder injury, replaced by Jeff Driskel, who was replaced by Brett Rypien — who was fun to watch in a bad game last week.

The Patriots are still waiting for Newton to come back from the COVID-19 list, and last week they started Brian Hoyer (who was terrible) before turning to Jarrett Stidham (also terrible). Adding to the mess is New England’s best defensive player, Stephon Gilmore, reportedly joining Newton on the COVID-19 list.

Pick: Patriots

Chargers at Saints

6:15 p.m. Monday ESPN Line: Saints -7.5 | Total: 50.5 Saints (2-2) running back Alvin Kamara is justifying his huge new contract by leading the NFL in yards from scrimmage and touchdowns. But there is no question that the Saints’ defense has disappointed, and if they give rookie quarterback Justin Herbert some room to make plays, the Chargers (1-3) could turn this into a game.

Pick: Chargers +7.5

Bills at Titans

5p.m. Tuesday CBS

Line: Off | Total: Off

The Titans (3-0) have dealt with coronavirus cases and the game has been moved.

The Bills (4-0) have been dominant on offense and would have a field day against Tennessee’s shoddy defense. The Titans, provided they don’t come in with too much rust from an unexpected week off, could be expected to score quite a bit against Buffalo’s struggling defense.

Pick: Bills

OTHER GAMES Bengals at Ravens

11 a.m.

Line: Ravens -13 | Total: 51

For a second consecutive week, the Ravens (3-1) are two-touchdown favorites, and the scary thing is, that’s somewhat reasonable since their average margin of victory in their three wins is 21 points. Baltimore’s defense has dominated against every team they’ve played with the exception of Kansas City, and its offense continues to thrive thanks to its enviable collection of running options and a passing game that is higher in quality than in quantity. The Bengals (1-21) are a poor match, as their defense is particularly susceptible to the run. But quarterback Joe Burrow has looked terrific over his first four games.

Pick: Bengals +13

Panthers at Falcons

11 a.m.

Line: Falcons -2.5 | Total: 53.5

If the Falcons (0-4) have a desperation mode, this is the time to engage it. Coach Dan Quinn almost has to be on the hot seat after a winless start and multiple dramatic collapses, and a game against the Panthers (2-2) is a challenge even at home. Carolina has played well in the past two weeks, spreading the ball around and beating two decent teams, the Chargers and the Arizona Cardinals.

Pick: Panthers +2.5

Rams at Washington

11 a.m.

Line: Rams -7.5 | Total: 45.5 Coach Ron Rivera believes the Footballers (1-3) have a shot at the playoffs thanks to their presence in the putrid NFC East.

His big solution for getting his team past division-leading Philadelphia (pause for chuckling) is to start Kyle Allen at quarterback rather than Dwayne Haskins when facing the Rams (3-1), a team that is more than capable of hanging 30-plus points on Washington’s defense. Maybe Alex Smith will see the field.

Pick: Rams -7.5

Jaguars at Texans

11 a.m.

Line: Texans -6 | Total: 54.5 Coach Bill O’Brien was fired last week. It seems as if the team finally noticed that quarterback Deshaun Watson’s prime years were being wasted, though that realization happened after O’Brien, in his GM role, had largely gutted the team. The good news for Romeo Crennel, who will take over on an interim basis, is that his team has an excellent chance to start off a new era with a win thanks to the visiting Jaguars (1-3) being the type of team that Watson should absolutely shred.

Pick: Texans -6

Cardinals at Jets

11 a.m.

Line: Cardinals -7 | Total: 47 The Cardinals (2-2) are suddenly reeling, having followed up a 2-0 start with consecutive losses, the second of which involved quarterback Kyler Murray averaging a meager 4.3 yards per passing attempt — a statistic that was quite likely heavily influenced by an ankle injury to wide receiver DeAndre Hopkins. It certainly isn’t where coach Kliff Kingsbury wants the Cardinals to be, but the Jets (0-4) have done an excellent job making other teams feel good about themselves this season.

Pick: Cardinals -7

Dolphins at 49ers

2:05 p.m.

Line: Off | Total: Off

Last week, the announcers somewhat shockingly discussed whether there was a quarterback controversy for the 49ers (2-2). The conjecture followed a few exciting plays from backup quarterback Nick Mullens, but by the end of the game, Mullens (200 yards, two interceptions) had been replaced by C.J. Beathard, and San Francisco had lost to the lowly Eagles. The team is probably going to stick with Jimmy Garoppolo, who guided them to the Super Bowl last season, once he’s healthy. That might not come this week, but as the 49ers’ roster continues to get healthier, a home game against the Dolphins (1-3) is winnable.

Pick: 49ers

Colts at Browns

2:25 p.m.

Line: Colts -1.5 | Total: 47 After allowing 27 points against Jacksonville in Week 1, the Colts (3-1) have allowed a total of 29 points over the past three weeks. They have their offense right where they want it, with a heavy focus on running the ball, and Philip Rivers has been a nice addition at quarterback. That run of good fortune may go on hiatus this week against the Browns (3-1), who are underdogs at home despite coming off three consecutive wins in which their offense has generated an average of 39.3 points. The Colts certainly have the defensive personnel to slow any team down, but even with running back Nick Chubb out for several weeks with a knee injury, Cleveland should still have a great chance of improving to 4-1 for the first time since 1994.

Pick: Browns +1.5