Vaccine said to be very protective in adolescents
The Pfizer-BioNTech coronavirus vaccine is extremely effective in young adolescents, perhaps even more so than in adults, the companies reported Wednesday — a finding that could speed a return to normalcy for millions of American families.
No symptomatic infections were found among children ages 12 to 15 who received the vaccine in a recent clinical trial, the drugmakers said; the children produced strong antibody responses and experienced no serious side effects.
Depending on regulatory approval, vaccinations could begin before the start of the next academic year for middle school and high school students, and for elementary school children not long after.
The companies announced the results in a statement that did not include detailed data from the trial, which has not yet been peer-reviewed nor published in a scientific journal.
Still, the news drew praise and excitement from experts.
Vaccination efforts are accelerating throughout the nation. As of Tuesday, 29% of Americans had received at least one dose of a coronavirus vaccine, and 16% had been fully inoculated, according to the CDC.
But the country cannot hope to reach herd immunity — the point at which immunity becomes so widespread that the coronavirus slows its crawl through the population — without also inoculating the youngest Americans, some experts say. Children younger than 18 account for about 23% of the U.S. population.
“The sooner that we can get vaccines into as many people as possible, regardless of their age, the sooner we will be able to really feel like we’re ending this pandemic for good,” said Angela Rasmussen, a virus expert affiliated with Georgetown University in Washington.
The trial included 2,260 adolescents ages 12 to 15. The children received two doses of the vaccine three weeks apart — the same amounts and schedule used for adults — or a placebo of saltwater.
The researchers recorded 18 cases of symptomatic coronavirus infection in the placebo group and none among the children who received the vaccine. Still, the low number of infections makes it difficult to be too specific about the vaccine’s efficacy in the population at large, Rasmussen said.
The adolescents who got the vaccine produced much higher levels of antibodies on average, compared with participants 16 to 25 years old in an earlier trial.
The children experienced the same minor side effects as older participants, although the companies declined to be more specific.