Miami (4-3) at Arizona (5-2)

Kickoff: 4:25 p.m. ET, State Farm Stadium; Glendale, AZ.

TV: CBS (Ch: 4 in Miami/Ft. Lauderdale and Ch: 12 in Palm Beach); RADIO: WQAM(560-AM), KISS (99.9FM), WQBA(1140-AM, Spanish) Coaches: Brian Flores 4-3 (9-14 in second season with Dolphins); Kilff Kingbury 5-2 (10-12 in second season with Cardinals) Series: The Dolphins lead the all-time series 9-3, but the Cardinals have won three out of the past four matchups.

Line: Miami is a 4 ½ -point underdog, with an over-under of 49.

Injuries: Dolphins— Questionable: DB Jamal Perry (foot); Out: RB Matt Brieda (hamstring), RB Myles Gaskin (knee), WR Lynn Bowden Jr. (reserve/COVID-19) Cardinals— Questionable: DL Jordan Phillips (hamstring), LB Zeke Turner (toe); Out: RB Kenyan Drake (ankle), CB Dre Kirkpatrick (thigh), LB Devon Kennard (reserve/COVID-19), CB Byron Murphy Jr. (reserve/ COVID-19)

Noteworthy: Dolphins rookie quarterback Tua Tagovailoa will make his second career start, facing second-year starter Kyler Murray and the Cardinals.

... Tagovailoa relied on a standout day by the Dolphins defense and special teams lastweek against the Rams in a subdued starting debut. But the Dolphins are optimistic they can open the playbook for their No. 5 pick against the Cardinals defense. ... On the other side, though, the Dolphins must stop the NFL’s most potent offense in yards gained. Murray and star receiver DeAndre Hopkins will test the Dolphins’ top-ranked scoring defense. ... The Dolphins plan to keep Hopkins in check with cornerbacks Xavien Howard and ByronJ ones, while the rest of the defense hopes Murray doesn’t break free up the field. ... Second-year coaches Flores and Kingsbury meet for the first time, as both are starting to see their franchise rebuilding efforts take shape.