DOLPHINS (1-6) vs. BILLS (4-2) Kickoff: TV:

1 p.m., Highmark Stadium, Buffalo

CBS (Chs: 4 in Miami-Dade/Broward and 12 in Palm Beach); RADIO: WQAM (560 AM), KISS (99.9 FM), WQBA (1140 AM, Spanish)

Coaches: Brian Flores is 16-23 in his third season with Dolphins; Sean McDermott is 44-32 in his fifth season leading the Bills.

Series: The Dolphins have a 61-53-1 edge in the all-time series, including postseason, but the Bills have won six straight over the Dolphins.

Line: The Dolphins are a 13 ½-point underdog; the over/ under is 49.

Injuries: Dolphins — Out: WR Preston Williams, S Sheldrick Redwine; Questionable: LB Jerome Baker (knee), WR DeVante Parker (shoulder/hamstring), C Greg Mancz (groin), CB Noah Igbinoghene (knee); Injured reserve: WR Will Fuller (finger), C Michael Deiter (foot/quad), RB Malcolm Brown (quadriceps), S Jason McCourty (foot), WR Lynn Bowden (hamstring), WR Allen Hurns (wrist), T Larnel Coleman (knee); Bills —

Out: TE Dawson Knox (hand); Doubtful: OL Spencer Brown (back); Questionable: DT Justin Zimmer (foot); Injured reserve: DE Bryan Cox (Achilles), WR Marquez Stevenson (foot).

Noteworthy: The Dolphins enter on a six-game losing streak, and it doesn’t get any easier against the divisional foe that now sits atop the AFC East. Buffalo has beaten Miami in six straight meetings, including all five times with Flores at the helm, and topped the Dolphins, 35-0, in Week 2 at Hard Rock Stadium this year. Last time they met in Orchard Park, the Bills ended Miami’s 2020 season in a 56-26 Week 17 mauling . ... Dolphins quarterback Tua Tagovailoa faces the team that he was injured against on Sept. 19, causing him to miss three weeks with fractured ribs. Tagovailoa makes his third start back and final one before the NFL trade deadline on Tuesday as Miami has been the subject of various trade rumors for Houston Texans quarterback Deshaun Watson . ... Fourth-year Bills quarterback Josh Allen is 6-1 in seven career games against the Dolphins with 19 touchdowns to five interceptions.