What we do, don't know about variant
South African scientists identified a new version of the coronavirus that they say is behind a recent spike in COVID-19 infections in Gauteng, the country’s most populous province.
It’s unclear where the new variant first emerged, but scientists in South Africa alerted the World Health Organization in recent days, and it has now been seen in travelers arriving in several countries, from Australia to Israel to the Netherlands.
On Friday, the WHO designated it as a “variant of concern,” naming it “omicron” after a letter in the Greek alphabet.
What do we know about omicron?
Health Minister Joe Phaahla said the variant was linked to an “exponential rise” of cases in the last few days.
From just over 200 new confirmed cases per day in recent weeks, South Africa saw the number of new daily cases rocket to more than 3,200 Saturday, most in Gauteng.
Struggling to explain the sudden rise in cases, scien- tists studied virus samples and discovered the new vari- ant. Now, as many as 90% of the new cases in Gauteng are caused by it, according to Tulio de Oliveira, director of the Kwazulu-natal Research
Innovation and Sequencing Platform.
Why are scientists worried about this new variant?
After convening a group of experts to assess the data, the WHO said that “preliminary evidence suggests an increased risk of reinfection with this variant,” as compared to other variants.
That means people who contracted COVID-19 and recovered could be subject to catching it again.
The variant appears to have a high number of muta-
tions — about 30 — in the coronavirus’ spike protein, which could affect how easily it spreads to people.
Sharon Peacock, who has led genetic sequencing of COVID-19 in Britain at the University of Cambridge, said the data so far suggest the new variant has mutations “consistent with enhanced transmissibility,” but said that “the significance of many of the mutations is still not known.”
Lawrence Young, a virologist at the University of Warwick, described omicron as “the most heavily mutated version of the virus we have seen,” including potentially worrying changes never before seen all in the same virus.
What’s known and not known about the variant?
Scientists know that omicron is genetically distinct from previous vari a nts including the beta and delta variants, but do not know if these genetic changes make it any more transmissible or dangerous. So far, there is no indication the variant causes more severe disease.
It will likely take weeks to sort out if omicron is more infectious and if vaccines are still effective against it.
Peter Openshaw, a profes- sor of experimental medi- cine at Imperial College London said it was “extremely
unlikely” that current vaccines wouldn’t work, noting they are effective against numerous other variants.
Even though some of the genetic changes in omicron appear worrying, it’s still unclear if they will pose a
public health threat. Some previous variants, like the beta variant, initially alarmed scientists but didn’t end up spreading very far.
“We don’t know if this new variant could get a toehold in regions where delta is,” said Peacock of the University of Cambridge. “The jury is out on how well this vari- ant will do where there are other variants circulating.”
To date, delta is by far the most predominant form of COVID-19, accounting for more than 99% of sequences submitted to the world’s biggest public database.
How did this new variant arise?
The coronavirus mutates as it spreads and many new variants, including those with worrying genetic changes, often just die out. Scientists
monitor COVID-19 sequences for mutations that could make the disease more transmissible or deadly, but they cannot determine that sim- ply by looking at the virus.
Peacock said the vari- ant “may have evolved in someone who was infected but could then not clear the virus, giving the virus the chance to genetically evolve,” in a scenario similar to how experts think the alpha variant — which was first identified in England — also emerged, by mutating in an immune-compromised person.
Are the travel restrictions being imposed by some countries justified?
Maybe.
Given the recent rapid rise in COVID-19 in South Africa, restricting travel from the region is “prudent” and would buy authorities more time, said Neil Ferguson, an infectious diseases expert at Imperial College London.
But the WHO noted that such restrictions are often limited in their effect and urged countries to keep borders open.
Jeffrey Barrett, director of COVID-19 Genetics at the Wellcome Sanger Institute, thought that the early detec
tion of the new variant could mean restrictions taken now would have a bigger impact than when the delta variant first emerged.
“With delta, it took many, many weeks into India’s terrible wave before it became clear what was going on and delta had already seeded itself in many places in the world and it was too late to do anything about it,” he said. “We may be at an earlier point with this new variant so there may still be time to do something about it.”
South Africa’s government said the country was being treated unfairly because it has advanced genomic sequencing and could detect the variant quicker and asked other countries to reconsider the travel bans.
Dr. Matshidiso Moeti,
WHO’S regional director for Africa, commended South Africa and Botswana for quickly informing the world about the new variant.
“With the omicron variant now detected in several regions of the world, putting in place travel bans that target Africa attacks global solidarity,” Moeti said. “COVID19 constantly exploits our divisions. We will only get the better of the virus if we work together for solutions.”