Study: No brain injuries for ‘Havana syndrome’ patients

WASHINGTON — An array of advanced tests found no brain injuries or degeneration among U.S. diplomats and other government employees who suffer mysterious health problems once dubbed “Havana syndrome,” researchers reported Monday.

The National Institutes of Health’s nearly five-year study offers no explanation for symptoms including headaches, balance problems and difficulties with thinking and sleep that were first reported in Cuba in 2016 and later by hundreds of American personnel in multiple countries.

But it did contradict some earlier findings that raised the specter of brain injuries in people experiencing what the State Department now calls “anomalous health incidents.”

“These individuals have real symptoms and are going through a very tough time,” said Dr. Leighton Chan, NIH’S chief of rehabilitation medicine, who helped lead the research. “They can be quite profound, disabling and difficult to treat.”

Yet sophisticated MRI scans detected no significant differences in brain volume, structure or white matter — signs of injury or degeneration — when Havana syndrome patients were compared to healthy government workers with similar jobs, including some in the same embassy. Nor were there significant differences in cognitive and other tests, according to findings published in the Journal of the American Medical Association.

While that couldn’t rule out some transient injury when symptoms began, researchers said it’s good news that they couldn’t spot long-term markers on brain scans that are typical after trauma or stroke.

That “should be some reassurance for patients,” said study co-author Louis French, a neuropsychologist at Walter Reed National Military Medical Center who treats Havana syndrome. “It allows us to focus on the here and now, to getting people back to where they should be.”

A subset, about 28%, of Havana syndrome cases were diagnosed with a balance problem called persistent postural-perceptual dizziness, or PPPD. Linked to inner-ear problems as well as severe stress, it results when certain brain networks show no injury but don’t communicate properly. French called it a “maladaptive response,” much like how people who’ve slouched to alleviate back pain can have posture trouble even after the pain is gone.

The Havana syndrome participants reported more fatigue, posttraumatic stress symptoms and depression.