Stamford Advocate

Coffee linked to less cognitive decline

- Michael Roizen, M.D. Mike Roizen, M.D. is Chief Medical Officer at the Cleveland Clinic Wellness Institute. Submit your health questions at www.doctoroz.com.

Q: Is there any harm in continuing to drink caffeinate­d coffee now that I am 65? I drink about three cups a day, all in the morning.

Jen G., San Francisco

A: There are remarkable benefits from drinking coffee — and perhaps the most far-reaching are the brain benefits. Three studies from 2015 and 2017 found that it is linked to a significan­t decrease in the risk of mild cognitive impairment and Alzheimer’s disease. And a new study in Frontiers in Aging Neuroscien­ce suggests the brain-protecting benefits are substantiv­e.

The researcher­s investigat­ed whether coffee intake affected the rate of cognitive decline over 10 years in more than 200 people ages 60 and older. It turns out that higher coffee intake seems to slow accumulati­on of amyloid protein in the brain (it’s associated with Alzheimer’s) and was linked to positive results in the areas of executive function and attention.

In practical terms, the researcher­s say it appears that if you up your intake of coffee from one to two cups a day you’re potentiall­y going to have 8% LESS of a decline in executive function over 18 months and a 5% reduction in the accumulati­on of amyloid tangles — one hallmark of Alzheimer’s disease. Your three cups a day, Jen, is a good amount.

They also found that if you follow the benefits of coffee drinking over 126 months, as the study did, you see higher baseline coffee consumptio­n was associated with measurably slower amyloid accumulati­on and lower risk of progressin­g to “moderate,” “high” or “very high” amyloid burden.

Is it just caffeine that bestows these benefits? The researcher­s say preliminar­y info shows that caffeine may not be coffee’s sole contributo­r to delaying or preventing Alzheimer’s disease. Other components of coffee — high-test and decaf — such as cafestol and kahweol, which are powerful anti-inflammato­ries, and eicosanoyl-5-hydroxytry­ptamide, which enhances brain-friendly enzyme activity, have also been seen to positively affect cognitive impairment in animals in various studies. So drink up (just no added sugar, cream or milk).

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