Texans 57, Titans 14
HOUSTON — Rookie Deshaun Watson threw for four touchdowns and ran for another as Houston scored the most points in franchise history.
Watson, the 12th pick in this year's draft, became the first rookie to throw four touchdowns and run for another one since Fran Tarkenton in 1961, and tied an NFL record for most touchdowns by a rookie quarterback.
The Texans (2-2) outdid their previous highest point total of 45 set in a victory over the Titans in 2014 and are the first NFL team to score 50 points since the Jaguars scored 51 in December 2015.
Saints 20, Dolphins 0
LONDON — Drew Brees threw for 268 yards and two touchdowns and the Saints scored all but three of their points in the second half.
Michael Thomas had a touchdown reception in the third quarter, Alvin Kamara added one in the fourth and Will Lutz made two of his three field-goal attempts for New Orleans (2-2), which arrived for the game on Monday and won the lowest-scoring game ever held in London.
Panthers 33, Patriots 30
FOXBOROUGH, Mass. — Graham Gano hit a 48-yard field goal as time expired, and the Carolina Panthers stunned New England.
The winner served as redemption for Gano, who missed an extra point in the third quarter.
It was the second home loss this season for the usually unbeatable Patriots at Gillette Stadium. The defeat marked just the second time since 2012 that Tom Brady has lost two home starts within a season.
Broncos 16, Raiders 10
DENVER — The Broncos throttled running back Marshawn Lynch and sent quarterback Derek Carr to the sideline with a back injury, then sealed their win on safety Justin Simmons' interception of EJ Manuel at the Denver 8 in the closing minutes.
Cardinals 18, 49ers 12, OT
GLENDALE, Ariz. — Carson Palmer threw 19 yards to Larry Fitzgerald with 32 seconds left in overtime for the game's only touchdown.
The scoring had been limited to nine field goals on an ugly afternoon in the desert before Palmer directed a seven-play, 75-yard drive with 1:52 to play.
Eagles 26, Chargers 24
CARSON, Calif. — Carson Wentz passed for 242 yards, LeGarrette Blount rushed for 136 and the Eagles extended their promising start to the season.
Buccaneers 25, Giants 23
TAMPA, Fla. — Jameis Winston threw for 332 and three touchdowns without an interception, and Nick Folk kicked a 34-yard field goal as time expired.
Bills 23, Falcons 17
ATLANTA — Stephen Hauschka kicked a tiebreaking, 56-yard field goal with less than five minutes remaining and the Buffalo Bills made a last-minute defensive stand.
Steelers 26, Ravens 9
BALTIMORE — Le'Veon Bell rushed for 144 yards and two touchdowns to seize first place in the AFC North.
Jets 23, Jaguars 20, OT
EAST RUTHERFORD, N.J. — Chandler Catanzaro kicked a 41-yard field goal with 28 seconds left in overtime, lifting the Jets.
Bengals 31, Browns 7
CLEVELAND — Andy Dalton threw three of his four touchdown passes in the first half and Cincinnati's offense found the perfect opponent to work out some early season struggles.