Novavax vaccine effective, but less so against variants
Novavax Inc. said Thursday that its COVID-19 vaccine appears 89% effective based on early findings from a British study and that it also seems to work – though not as well – against new mutated versions of the virus circulating in that country and South Africa.
The announcement comes amid worry about whether a variety of vaccines being rolled out around the world will be strong enough to protect against worrisome new variants – and as the world desperately needs new types of shots to boost scarce supplies.
The study of 15,000 people in Britain is still underway. But an interim analysis found 62 participants have been diagnosed with COVID-19 – only six in the group that got vaccine and the rest who received dummy shots.
The infections occurred at a time when Britain was experiencing a jump in COVID-19 caused by a more contagious variant. A preliminary analysis found more than half of the trial participants who became infected had the mutated version. The numbers are small but Novavax said they suggest the vaccine is nearly 96% effective against the older coronavirus and nearly 86% effective against the new variant. The findings are based on cases that occurred at least a week after the second dose.
“Both those numbers are dramatic demonstrations of the ability of our vaccine to develop a very potent immune response,” Novavax CEO Stanley Erck said in a call with investors late Thursday.
Scientists have been even more worried about a variant first discovered in South Africa that carries different mutations. Results from a smaller Novavax study in that country suggested the vaccine does work but not nearly as well as it does against the variant from Britain.
The South African study included some volunteers with HIV. Among the HIV-negative volunteers, the vaccine appears 60% effective. Including volunteers with HIV, overall, the protection was 49%, the company said. Although genetic testing still is underway, so far about 90% of the COVID-19 illnesses found in the South African study appear to be the result of the new variant.
“These are good results. There is reason to be optimistic” about the 60% effectiveness, said Glenda Gray, head of the South African Medical Research Council. Even against the new variant that now causes more than 90% of new cases in that country, “we’re still seeing vaccine efficacy,” she said.
More concerning is what the study showed about a totally different question – the chances of people getting COVID-19 a second time, said the leader of the South African study, Shabir Madhi of the University of the Witwatersrand in Johannesburg. Tests suggested that nearly a third of study participants had been previously infected, yet rates of new infections in the placebo group were similar.
Novavax said it needs some additional data before it can seek British authorization for the vaccine’s use, sometime in the next month or so. A larger study in the U.S. and Mexico has enrolled slightly more than half of the needed 30,000 volunteers.