Will hormone replacement therapy prevent wrinkles?

Q: I just read your column that says taking calcium and vitamin D doesn’t strengthen bones. I didn’t buy the recommendation, so I’ve never taken either. My theory is, if you want strong bones, run, walk and jump up and down.

But at one time my OB-GYN doctor told me that if I wanted to keep strong bones and look youthful, I should take hormone replacement therapy. My doctor up north said that was nonsense.

However, my two women friends who take HRT look fabulous at 70, whereas I started looking like the proverbial withered hag in my mid-50s after menopause. Coincidence? Genetics? I wish I had followed the advice of the first doctor. My bones are OK, but my face! What say you?

A: Hormone replacement therapy may slow skin aging and reduce the likelihood of osteoporosis (BioMed Research International, Dec. 21, 2013). That said, possible side effects such as blood clots, gallbladder disease, breast cancer and heart disease should be considered before starting HRT for cosmetic purposes ( JAMA, Dec. 12, 2017).

Q: I had a major cardiac event that I am lucky to have survived. About three months later, I developed a horrible case of psoriasis. I had open lesions on the palms of my hands and my feet. Bathing was sheer agony, and I could barely walk.

I suffered with this for about a year and a half. I suspected that atorvastatin was causing my problem and asked my doctors about it. Both the cardiologist and the dermatologist said that there was no connection between the statin and my psoriasis.

I finally did a Google search that led me to a case report from the Department of Dermatology at the University of Genoa, Italy, in 2009. It conclusively proved that atorvastatin can worsen a case of psoriasis. I contacted Pfizer, which referred me to the article that I had already discovered. Why didn’t my doctors know this fact?

As soon as I read that clinical study, I immediately discontinued the atorvastatin, and my psoriasis started to improve. Please inform the public. I suffered needlessly for a year and a half just because my physicians didn’t know about this adverse reaction.

A: Psoriasis is not listed as a side effect of atorvastatin in the prescribing information. That may be why your physicians were unaware of it.

We were able to track down the article you referred to ( Journal of Dermatological Case Reports, Dec. 30, 2009). Another case report describes a psoriasislike reaction to pravastatin (Case Reports in Dermatological Medicine, July 31, 2017). The authors note that statins often may be overlooked as the cause of skin reactions.