Study finds new links between viruses and Alzheimer’s disease

WASHINGTON — Viruses that sneak into the brain just might play a role in Alzheimer’s, scientists reported Thursday in a provocative study that promises to reignite some long-debated theories about what triggers the mind-robbing disease.

The findings don’t prove viruses cause Alzheimer’s, nor do they suggest it’s contagious.

But a team led by researchers at New York’s Mount Sinai Health System found that certain viruses — including two extremely common herpes viruses — affect the behavior of genes involved in Alzheimer’s.

The idea that infections earlier in life might somehow set the stage for Alzheimer’s decades later has simmered at the edge of mainstream medicine for years. It’s been overshadowed by the prevailing theory that Alzheimer’s stems from sticky plaques that clog the brain.

Thursday’s study has even some specialists who never embraced the infection connection saying it’s time for a closer look, especially as attempts to block those so-called beta-amyloid plaques have failed.

“With an illness this terrible, we cannot afford to dismiss all scientific possibilities,” said Dr. John Morris, who directs the Alzheimer’s research center at Washington University School of Medicine in St. Louis. He wasn’t involved in the new research but called it impressive.

The study also fits with mounting evidence that how aggressively the brain’s immune system defends itself against viruses or other germs may be riskier than an actual infection, said Alzheimer’s specialist Dr. Rudolph Tanzi of Mas- sachusetts General Hospital. With Harvard colleague Dr. Robert Moir, Tanzi has performed experiments showing that sticky beta-amyloid captures invading germs by engulfing them — and that’s why the plaque starts forming in the first place.

The team from Mount Sinai and Arizona State University came up with some viral suspects — by accident. The study, funded by the National Institutes of Health, wasn’t hunting viruses but was looking for new drug targets for Alzheimer’s. The researchers were using complex genetic data from hundreds of brains at several brain banks to compare differences between people who’d died with Alzheimer’s and the cognitively normal.

The first clues that viruses were around “came screaming out at us,” said Mount Sinai geneticist Joel Dudley, a senior author of the research published Thursday in the journal Neuron.

Since 1980, other researchers have linked a variety of bacteria and viruses to an increased risk of Alzheimer’s. But it was never clear if germs were bystanders or actively spurring Alzheimer’s.

The new study went farther: Researchers used computer models to check how the viral genes interacted with human genes, proteins and amyloid buildup, almost like the viruses’ social media connections, Dudley explained.

They found a lot of interactions, suggesting the viruses could even switch on and off Alzheimer’s-related genes. To see if those interactions mattered, the researchers bred mice lacking one molecule that herpes seemed to deplete. Sure enough, the animals developed more of those amyloid plaques.

CHRIS SWEDA / CHICAGO TRIBUNE Doug Brown (second from right), a resident of Silverado Memory Care near Chicago, plays the guitar during a music therapy program earlier this year for people with dementia and Alzheimer’s disease. A new study links viruses to Alzheimer’s.