Extra weight could be deadly with COVID-19

FORTLAUDERDALE,FLA.— Dr. Craig Mallak’s work in the morgue tracking Broward County’s COVID-19 deaths startled him so much he shed pounds that he didn’t even need to lose.

“Obesity is a factor in a lot of cases,” Mallak, Broward’s chief medical examiner, said in an email. “Motivated me to lose 18 pounds in June, and I’m not overweight to start with.”

The dominant message so far in the pandemic is that older people are the most at risk. That’s true, but doctors on the front lines of South Florida’s outbreak are also finding obesity is making it harder for people to fight off the virus, regardless of age.

That could have grave implications for the United States, which has one of the highest obesity rates in the world, said Dr. Cate Varney, an obesity specialist at the University of Virginia Health System.

“A colleague asked me, ‘Do you think it will get as bad as Italy?’” Varney recalled. “I said, ‘No, it’s going to be worse because we have higher rates of obesity.’ This is a definite call to action. We can start now, but we need to be prepared at the end of this pandemic to really start taking obesity more seriously.”

It’s not just a few extra pandemic pounds that should spark worry, according to the Centers for Disease Control and Prevention’s guidelines.

Specifically, people who have a body-mass index greater than 30 are at higher risk, said Dr. Sunil Kumar, medical director of intensive care at Broward Health

Medical Center. Body-mass index varies by height and weight. A person who is off the normal weight by about 40 pounds could be considered obese.

A man of average height — 5 feet, 9 inches — would be considered obese at 203 pounds, while a woman of average height — 5 feet, 4 inches — would meet that mark at 175 pounds, according to a BMI calculator.

Studies are showing that younger patients with COVID19 who are admitted to the hospital are more likely to have obesity as an underlying factor. That’s been backed up by Kumar’s own observation in the ICU.

“The spread of this disease has significantly changed from the first wave,” Kumar said. “I am seeing a lot more younger patients. I even have patients in the ICU as young as 19 who are really, really sick.”

Varney, the obesity specialist, said several possible explanations exist as to why COVID-19 patients who are overweight tend to have worse outcomes. Research is still being done, and scientists don’t have a definitive explanation yet.

One theory is that people with obesity have more Ace2 receptors on their cells. The virus uses these receptors to infect cells and then make copies of itself.

“If you have obesity, you have more Ace2 receptors so you are going to have a higher viral load, and it takes longer for virus to get out of your body,” Varney said.

People with obesity are also susceptible to low-grade chronic inflammation, which has been associated with worse outcomes.

Another factor could be that being overweight compresses the lungs, leading to smaller lung capacity. Obesity is linked with other chronic illnesses, such as high blood pressure, heart disease and Type 2 diabetes, that heighten the risk.

“This is what I am telling my obesity management patients: ‘This is not about vanity,’” Varney said. “‘This is not about looking good in clothes. What this virus has shown to us and needs to be taken seriously and recognized is the impact obesity has on your health and your life. It can be the difference between life and early death.‘”

Varney said telling people to eat less and exercise more is an oversimplification of a complex condition that is too often stigmatized, misunderstood and maligned by the public. Obesity has environmental, societal and genetic components that make it difficult to treat, she said.

While exercising and eating healthy is good advice, it isn’t a substitute for wearing a mask, washing hands and keeping physical distance from others, said Kumar, the ICU doctor.

Younger people who are at a normal weight also shouldn’t let their guard down, he said. Kumar has seen otherwise healthy younger patients in the ICU.

“It makes you really upset with all this disease and death that we are seeing people who are not taking this seriously,” he said. “The best thing for people to do is protect themselves and others.”