The Atlanta Journal-Constitution

Viral testing mitigates COVID-19 spread

Georgia Tech’s use of widespread testing as a cornerston­e of its pandemic fighting toolkit shows encouragin­g results.

- By Joshua S. Weitz and Greg Gibson Joshua S. Weit zand Greg Gibson are both Patton Distinguis­hed Professors of Biological Science and on the faculty of the Petit Institute for Bioenginee­ring and Bioscience at Georgia Tech.

An urban campus of a large public university. An average of 1,500 free, noninvasiv­e tests performed daily for an on- campus community of more than 10,000 students, staff and faculty. Test results returned in 36 hours. Contact tracing and assistance with isolation for those who test positive. Mask- wearing required indoors. Positivity rate reduced from almost 5% to less than 1% in a few weeks — stably maintained for a month ( and counting). Sounds too good to be true? It isn’t.

This is the reality unfolding at Georgia Tech, where we have worked with a collaborat­ive team of scientists and engineers to develop a large- scale viral testing program along with mask- wearing and hybrid teaching modes to help control the spread of COVID- 19. In contrast to large- scale outbreaks on many other college campuses, the use of communityw­ide testing as an interventi­on rather than a form of diagnosis is feasible, scalable and urgently needed — not just for the Georgia Tech campus community, but for colleges and universiti­es, K- 12 schools and businesses at large. It is the bridge between safety and renewed economic and social life.

The program’s design hinges upon a simple idea: Rather than wait for an infection to run its course, whether with or without symptoms, we have used large- scale viral testing to identify and isolate infected individual­s, thus removing them from potential risky interactio­ns. Our PCR test is saliva- based, thus simple, safe and specific. With

it, we can potentiall­y identify infected individual­s at early stages, even when their chance of infecting others is low. But that’s the point: Catching a case early may help to isolate individual­s before they become highly infectious, thereby stopping chains of transmissi­on

before they start. In doing so, we reduce the chance that one case becomes a few and a few cases become many.

This was not going to be easy. Georgia Tech started its term in mid- August amid significan­tly elevated rates of spread in the state. More than 7,500 undergradu­ates returned to on- campus residences, including dorms and Greek houses ( which promptly held their rush week), and thousands more students, staff and faculty began to return to study, work and teach on campus. Circulatin­g levels meant that we expected on the order

of 50 to more than 100 introduced cases, which would have increased rapidly with unchecked transmissi­on.

With the help of a logistics and communicat­ions team, we used communityw­ide town halls and open messaging to urge greater than 90% testing of individual­s in every Greek house and dorm. The purpose of such high testing rates was to establish voluntary testing as a social norm and to identify anomalies, e. g., a cluster of a few cases, before it was too late. However, even if testing rates did not always reach benchmarks, they have remained consistent­ly high enough to provide sentinel informatio­n and redirect intensive, follow- up testing as needed.

Indeed, after reopening there was a rapid growth in cases, such that two weeks after we started testing, the positivity rate increased from less than 1% to nearly 5%. Early identifica­tion of positive cases meant that we could intensify and concentrat­e testing efforts to target likely clusters — whether in hard- hit Greek houses or in shared living spaces in residence halls. This intensive testing — informed by risk factors ( like sharing a twin room or quad) — was then followed up by tracing and isolation that helped to stop chains of transmissi­on before they expanded. The students bought in, the vast majority follow the guidelines by wearing masks and taking the risk associated with transmissi­on seriously. The strategy is working.

September 10. That is the last time the positive test rate in our surveillan­ce testing program exceeded 1%, and some days in October it has been one tenth of even that. There is a long way to go, but at least now we can begin to contemplat­e what the new norm of campus life will look like with low positivity for the rest of the gall, and plan for the spring term.

There have been far too few success stories in the response to COVID- 19, particular­ly in Georgia. As yet, our success has not been replicated across the University System of Georgia or across the state, but that doesn’t diminish its relevance. Our message is simple: Science works, particular­ly when leaders enable science to influence and empower policy and action.

 ?? JEFF AMY/ AP ?? Agraduate assistant sits in anempty auditorium during an online lecture on the first day of classes at Georgia Tech in August. A proactive, science- based regimen of viral testing and contact tracing at the institute has drasticall­y reduced the number and rate of COVID- 19 infections on campus.
JEFF AMY/ AP Agraduate assistant sits in anempty auditorium during an online lecture on the first day of classes at Georgia Tech in August. A proactive, science- based regimen of viral testing and contact tracing at the institute has drasticall­y reduced the number and rate of COVID- 19 infections on campus.
 ??  ?? Greg Gibson
Greg Gibson
 ??  ?? Joshua S. Weitz
Joshua S. Weitz

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