Survivors struggle as scientists race to solve COVID mystery
On pandemic’s first anniversary, some COVID-19 survivors struggle with long-term symptoms
There was no reason to celebrate on Rachel Van Lear’s anniversary. The same day a global pandemic was declared, she developed symptoms of COVID-19. A year later, she’s still waiting for them to disappear. And for experts to come up with some answers.
The Texas woman is one of thousands of self-described long-haulers, patients with symptoms that linger or develop out of the blue months after they first became infected with coronavirus. Hers first arrived March 11, 2020.
The condition affects an uncertain number of survivors in a baffling variety of ways.
“We’re faced with a mystery,” said Dr. Francis Collins, chief of the National Institutes of Health.
Fatigue, shortness of breath, insomnia, trouble thinking clearly and depression are among the many reported symptoms. Organ damage, including lung scarring and heart inflammation, have also been seen. Pinpointing whether these symptom are directly linked to the virus or perhaps to some preexisting condition is among scientists’ tasks.
‘’Is it just a very delayed recovery or is it something even more alarming and something that becomes the new normal?’’ Collins said.
There are a few working theories for what might be causing persistent symptoms. One is that the virus remains in the body at undetectable levels yet still causes tissue or organ damage. Or it overstimulates the immune system, keeping it from returning to a normal state. A third theory: Symptoms linger or arise anew when the virus attacks blood vessels, causing minute, undetectable blood clots that can wreak havoc throughout the body.
Some scientists think each of these may occur in different people.
Dr. Steven Deeks, an infectious disease specialist at the University of California, San Francisco, said researchers first need to create a widely accepted definition of the syndrome. Estimates are “all over the map because no one is defining it in the same way,’’ he said.
Deeks is leading one study, collecting blood and saliva samples from volunteers who will be followed
for up to two years.
Some people develop long-term problems even when their initial infections were silent. Deeks said some evidence suggests that those who initially get sicker from a coronavirus infection might be more prone to persistent symptoms, and women seem to develop them more than men, but those observations need to be confirmed,
Deeks said.
Van Lear says she was in great shape when she got sick. At 35, the suburban Austin woman had no other health issues and was a busy mother of three who often worked out. First came a chest cold, then a high fever. A flu test came back negative, so her doctor tested for COVID-19. Soon after she developed blinding headaches,
debilitating fatigue and nausea so severe that she needed emergency room treatment.
‘’I was very scared because no one could tell me what was going to happen to me,’’ Van Lear said.
Over the next several months, symptoms would come and go: burning lungs, a rapid heartbeat, dizzy spells, hand tremors and hair loss. While most have disappeared, she still deals with an occasional racing heartbeat. Heart monitoring, bloodwork and other tests have all been normal.
Fatigue, fever, and no taste or smell were Karla Jefferies’ first symptoms after testing positive last March. Then came brain fog, insomnia, a nagging smell of something burning that only recently disappeared, and intermittent ringing in her ears. Now she can’t hear out of her left ear.
Doctors can’t find anything to explain it, and she bristles when some doctors dismiss her symptoms.
‘’I understand that COVID is something that we’re all going through together but don’t brush me off,’’ said Jefferies, 64, a retired state worker in Detroit.
As an African American woman with diabetes and high blood pressure, she was at high risk for a bad outcome and knows she’s lucky her initial illness wasn’t more serious. But her persistent symptoms and home confinement got her down and depression set in. Still, Jefferies wants to know what role the virus has played.
“I’m a year in, and to still from time to time have lingering effects, I just don’t understand that,’’ Jefferies said.