The Columbus Dispatch

Scientific approach to opioid crisis saves lives

- Abbie Roth is a senior science writer for Clinical & Research Communicat­ion at Nationwide Children’s Hospital and managing editor of Pediatrics Nationwide and Pediatrics­Nationwide.org. abbie.roth@nationwide­childrens.

FAbbie Roth

rom mid-2016 to mid-2017, more than 5,200 opioid overdose deaths were recorded in Ohio, making it the third-deadliest state for overdoses, according to the Centers for Disease Control and Prevention. The opioid epidemic — declared to be a national public health emergency in October 2017 — claimed more U.S. lives in 2016 than were lost in the Vietnam War.

And yet, those statistics don’t come close to tallying the loss experience­d by children. Their parents are dying. They live in unstable environmen­ts. They are born addicted and spend their first weeks in withdrawal. They are becoming addicted as teens, repeating the pattern.

Addiction and the opioid crisis affect every demographi­c — every age, gender, ethnicity and pay grade. The problem is complex, and so are the solutions. One sector or institutio­n can’t solve it all, but how can pediatric health care help?

Quality improvemen­t, or QI, is one way. It’s a systematic framework used to improve how care is delivered to patients. It’s not officially a research study, but it uses scientific methods and principles of measuremen­t, analysis and control with a specific aim. When targeted at problems resulting from addiction or, better yet, preventing addiction, the impact of QI can be profound.

For example, babies with neonatal abstinence syndrome (NAS) experience withdrawal because they were born to mothers who were using opioids, sometimes illicitly, sometimes appropriat­ely under doctors’ orders. The Ohio Perinatal Quality Collaborat­ive developed an extensive QI program, including weaning protocols to systematic­ally reduce the amount of medication needed to manage the infants’ withdrawal symptoms, greater investment in supportive care such as breastfeed­ing and cuddling, and expanded staff and parent education. As a result, babies with NAS in Ohio are spending less time in the neonatal ICU and experienci­ng better outcomes.

Sometimes, children require medication to manage pain because of an illness or injury. Because of QI initiative­s at Nationwide Children’s Hospital, physicians are writing fewer prescripti­ons for opioids and fewer pills per prescripti­on, after discoverin­g that most patients did not use all the pills ordered. Additional­ly, QI initiative­s have improved education for families about safe usage, storage and disposal of medication­s.

People with behavioral­health concerns are at a higher risk for addiction. In many cases, substance abuse begins as an attempt to selfmedica­te against depression, anxiety or other behavioral­health problems. Screening for behavioral-health concerns in primary-care visits and when prescribin­g medication in the case of an illness or injury can help identify those at risk for addiction. Many practices are using QI to increase the rates and effectiven­ess of their screening for behavioral-health concerns.

Adolescent­s and young adults with addiction need comprehens­ive treatment. Medication-assisted treatment combined with therapy from a profession­al trained in addiction and dual diagnosis can help them maintain sobriety. However, retention in a substance-abuse program is a major challenge. From 2009 to 2012 at Nationwide Children’s, only 9 percent of patients stayed in the program for 12 months. Through a QI project, retention increased to 40 percent at 12 months and 60 percent at six months.

These are just a few examples of how QI can help children and families affected by the opioid crisis. Furthermor­e, research can help us answer additional questions about addiction, recovery and prevention. That’s another topic for another column.

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