The Columbus Dispatch

US may need France-like lockdowns to beat COVID-19

- Sam Fazeli Columnist

The coronaviru­s pandemic hasn’t finished with us yet. A spike in infections in recent weeks has sent new cases to records in a number of places around the world including the U.S., which already weathered two waves of outbreaks this year. And the weather is only starting to turn cold.

Europeans have started taking draconian action again, despite the potential drag their economies. France has introduced a new lockdown that is only slightly less harsh than the one it imposed in the spring. Germany has opted for lockdown-lite. So what is the U.S. going to do?

Hospitaliz­ations, which had been on the decline, are now rising again, with some health systems feeling the strain. In Wisconsin, a field hospital was opened on the state’s fairground­s to accommodat­e patients, while capacity in El Paso, Texas, is so overtaxed that a county judge imposed stay-at-home orders.

Elsewhere, though, and as a whole, hospitaliz­ations are nowhere near where they were during the previous big outbreaks. As a result, there is a risk that the administra­tion, governors and the public misinterpr­et the severity of this latest wave or downplay the danger beyond a few hot spots. This would be a mistake, and a good look at the data shows why.

During the first wave – which was centered around the New York area from March 3 to June 11 – COVID-19 case counts led hospitaliz­ations by about a week. That gap stretched to about two weeks during the second “Sun Belt” wave from June 11 to Sept. 14, and has now grown to an even longer three weeks in the current third wave. It also appears that the ratio of people in the hospital to the number of positive cases has fallen dramatical­ly in the second and third wave. Here is where the risk of complacenc­y rises.

There are several ways to explain this evolution. First, it is very likely that the number of infections in the first wave were significantly undercount­ed. This was not only driven by the fact that we did not have access to routine tests and facilities at first, but also, many never got checked out to begin with.

Second, the latest wave is driven by younger individual­s. While there is risk of severe COVID-19 and “long COVID” in this group, they have a much lower rate of hospitaliz­ations. But they can certainly still spread the disease. Given the incubation period for the virus and the fact that many younger people are likely to be asymptomat­ic, we would expect many of them to pass on the infection to older members of their families without realizing it. In time, as more elderly people become sick, you’d expect to see an increase in hospitaliz­ations.

Another key difference from prior waves is our increased knowledge of COVID-19 and how to treat it. This has made us more stringent in deciding who gets hospitaliz­ed. During the first wave, clinicians had no idea what they were dealing with and outpatient settings didn’t know how to handle patients with moderate to severe illness. So the hospitaliz­ation rate was much higher.

This time around, people who are being hospitaliz­ed are likely to have much more severe cases of the disease, which means a bigger strain on intensive care units. The good news is that mortality rates are likely to be lower this time around as we already have better treatments. But hospitals may still be just as burdened, raising the prospect of delays in elective procedures and other care.

This latest COVID-19 wave isn’t taking the same course as the prior ones, but it looks likely to end up with the same result or worse: an acute health crisis in hospitals. How can we avoid this? Proper mitigation tactics – masking, social distancing, hand-washing – should be standard operating procedure. But it may take more than that.

In the coming winter months, we will tend to gather more indoors, where the virus has a very a good chance of being transmitte­d. A vaccine won’t be ready for broad deployment until well into 2021, assuming current clinical trials of experiment­al vaccine technologi­es work. States and local government­s will likely need to put curbs on people mixing. Given the experience in Europe, lockdowns – or something very close to that – may be the only option.

Sam Fazeli is senior pharmaceut­icals analyst for Bloomberg Intelligen­ce and director of research for EMEA.

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