The Columbus Dispatch

Merck spends $11.5B for Acceleron Pharma

- Tom Murphy

Merck will spend about $11.5 billion to buy Acceleron Pharma and its potential treatment for high blood pressure in vessels that connect the lungs and heart.

Merck will pay $180 per share in cash for Acceleron, the Kenilworth, New Jersey, company said Thursday.

Acceleron is running late-stage studies of a potential treatment called sotatercep­t for patients with life-threatenin­g pulmonary arterial hypertensi­on.

Blood vessels in the lungs become narrowed, blocked or destroyed in pulmonary arterial hypertensi­on, according to the Mayo Clinic. Blood pressure in lung arteries rises and causes the heart to worker harder, which can lead to heart failure.

Sotatercep­t represents a “potential blockbuste­r” and a way for Merck to add a new source of revenue, Mizuho Securities USA analyst Mara Goldstein wrote.

Merck executives told analysts Thursday they hope to launch the drug in 2024 or 2025, and it has multi-billion dollar peak sales potential.

“We are convinced that sotatercep­t has the potential to be a foundation­al therapy,” Merck CEO Rob Davis said.

Merck has long faced investor criticism that it’s too dependent for revenue from its drug Keytruda, which is now approved for treating a dozen types of cancer.

Keytruda brought in $4.2 billion for Merck in the second quarter, more than one-third of the company’s total revenue. Merck also is developing a potential COVID-19 treatment, and the company expects to have results from late-stage research into that drug later this year.

Acceleron also makes Reblozyl, a treatment for anemia in some rare blood disorders.

The company developed and sells that drug through a collaborat­ion with another drugmaker, Bristol Myers Squibb Co., which also is the largest institutio­nal shareholde­r in Acceleron, with more than an 11% stake.

Reblozyl has received approval from regulators in the United States, Europe, Canada and Australia.

Acceleron booked $25.6 million in royalty revenue in the second quarter from Reblozyl, which generated $128 million in sales.

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