The ethics of receiving a pig’s heart: Should an ex-con get one?
Bioethicist: Not yet clear if recipient got a gift or a curse
When David Bennett Sr., 57, agreed to accept a pig heart as a replacement for his own failing one, he took a huge chance.
His surgeon said he couldn’t promise whether Bennett would survive an extra day, week or year with the new heart because a gene-edited pig heart had never been tested in a person before.
Some have questioned whether Bennett, who served time in prison for stabbing a man 34 years ago, should have been given a second shot at life.
But it’s not yet clear whether Bennett got a gift or a curse, said Art Caplan, a bioethicist at New York University Langone Medical Center.
“I have seen so many first, cuttingedge experiments fail,” Caplan said. “What’s going on here is more like: How do you pick which test pilot is going to fly the first new dangerous aircraft?”
The first recipient of a permanent artificial heart, Barney Clark, “suffered horribly, begged his investigator who gave him the artificial heart to shut the thing off and let him die and they wouldn’t do it,” Caplan said.
Clark died in 1983, 112 days after receiving the device. He never left the hospital.
Jesse Gelsinger, one of the first recipients of gene therapy, endured a “horrible death” when his immune system went into overdrive, Caplan said, and Stephanie Fae Beauclair, a newborn who lived for 21 days in 1984 with a baboon heart beating inside “would have died (anyway), but died more miserably than she would have if she hadn’t been in an experiment.”
Hank Greely, director of the Center for Law and the Biosciences at Stanford School of Medicine, agreed that being first is a risky position.
“The odds that this is going to help him significantly in the long-run ... are very small,” Greely said. “Some people will say, ‘Yeah, but that’s better than dying.’ But that’s not necessarily true.”
It’s not clear exactly what Bennett understood or expected about the surgery, which was carefully explained to him after all his other treatment options had been exhausted. He has not yet spoken publicly after the transplant, though his recovery is going well. But his son said he wanted to live and knew that even if he didn’t, the experience would help others.
“Bioethicists love to think that research participants are motivated by altruism,” Greely said. “Far more are probably motivated by probably exaggerated hope.”
As to whether Bennett’s past should have influenced his shot at a new heart, the ethicists and doctors were unanimous: no.
Doctors treat the patient and don’t make judgments about whether the person is deserving or not, said Karen Maschke, a research scholar at The Hastings Center in Garrison, New York, who has a federal grant to study the ethics of using animal organs in people.
“Should doctors treat someone convicted of a financial crime but not a violent one?” Maschke said. Someone who was wealthy versus someone who wasn’t? “How do you make those kind of decisions about people’s behaviors?”
Caplan said a big question with an experiment like xenotransplantation is “when are you ready to try?”
At NYU, he came up with the idea of first testing the pig organ on a recently deceased person, just as he has suggested that drug companies and gene therapists first try their approach on the recently deceased before the living.
In September, NYU Langone transplant surgeon Robert Montgomery experimentally attached a pig kidney to a recently declared brain-dead person. The kidney seemed to function well and the woman’s body didn’t mount the kind of immediate immune reaction that has stopped xenotransplantation for decades.
As the researchers in Maryland, Montgomery used a pig whose genes had been edited to prevent rejection, though only one gene was deleted, while the University of Maryland School of Medicine researchers used a pig with 10 gene edits.
In an essay provided to Newsweek, lead surgeon Bartley Griffith said he’d long been inspired by “firsts” in medicine.
“I came out of that arena of gladiators. People who took on disease and were kicking and fighting their way to new knowledge to help patients,” he wrote.
Griffith said all he knew about Bennett was that he’d recently driven a bus for nursing home patients – not about his criminal record.
“We don’t look at incarceration history and things like that, I think that’s unethical,” Griffith wrote.
When Bennett woke up after the surgery, he thanked Griffith for saving his life.
“It made me cry. It’s simple, but he meant it and it was pretty special,” Griffith wrote. “All patients are precious to their surgeons. In the field I work in, you have to have selective memory in order to come to work every day. Not everything works out.”
Griffith said he’s proud to have been a part of the groundbreaking surgery and sees no ethical issues in placing a human life in front of a pig’s.
He said he would not agree to use organs from primates, but pigs are “far away from humans” genetically. “I’m honestly respectful of the opposite opinion.”
The ethicists said they see no problem sacrificing pigs for the sake of extending human lives.
Maschke said she hopes the scientific world will eventually move away from using animals, but that time hasn’t yet arrived.
Greely said he loves bacon and “if eating an animal is OK when there are lots of substitutes for that protein, using an organ to keep someone alive when there aren’t substitutes” should be OK too.
Caplan agreed.
“The place to worry about animal welfare is breakfast, not the medical use of pigs,” Caplan said.
“Those pigs, the ones that are genetically engineered are raised on special farms, obviously have to be very healthy, can’t be stressed and never suffer – they kill them, that’s true, but it’s not the same at all as factory farming and some of the terrible practices that millions and millions and millions of pigs are subjected to,” Caplan said. “The equation for me comes out (for) saving human lives.”
Caplan also quickly disposed of the argument some people have made that extending human lives will contribute to overpopulation.
“If you start down that road, you have to close down medicine,” he said. “The route to controlling overpopulation is doing something about reproduction, not letting the sick die.”