The Denver Post

Glaxo pays $300M for customers’ genetic data

- By Joseph N. Distefano

If you’ve ever wondered what the mail-away genetestin­g service 23andme was doing with all the personal and family bio-informatio­n collected from its five million customers, here’s one answer: Selling it to Glaxosmith­kline Plc, the British drug giant so Big Pharma can use your informatio­n to target and treat your genetic defects, boosting sales and profits.

Glaxo said it has agreed to invest $300 million in 23andme, the Mountain View, Calif., gene-testing company best known for its retail gene reports designed to suggest where your ancestors hail from. The company says more than four-fifths of 23andme customers — or more than 4 million people — agreed when they signed up with the service to let their data be used for research, and now Glaxo’s going to use it.

Anticipati­ng privacy concerns that people who sent samples to 23andme will be publicly identified as subject to genetic diseases, the companies stressed in their joint statement that they “have stringent security protection­s in place when it comes to collecting, storing and transferri­ng informatio­n about research participan­ts,” including data encryption.

Glaxo said in this statement that it plans “an exclusive four-year collaborat­ion that will focus on research and developmen­t of innovative new medicines and potential cures, using human genetics as the basis.” Glaxo plans to put “23andme’s large-scale genetic resources” collected from its “consenting” customers, together with GSK’S own science and marketing, to “discover novel drug targets” for “serious unmet medical needs.”

“We are excited about this unique collaborat­ion, as we know that drug targets with genetic validation have a significan­tly higher chance of ultimately demonstrat­ing benefit for patients and becoming medicines,” said Hal Barron, president of research and developmen­t and Chief Scientific Officer at Glaxo. “Partnering with 23andme, an organizati­on whose vision and capabiliti­es are transformi­ng the understand­ing of how genes influence health, will help to shift our research and developmen­t organisati­on to be ‘driven by genetics,’ and increase the impact GSK can have on patients.”

“Many” 23andme customers have asked for “cures or treatments” for genetic diseases, 23andme CEO and co-founder Anne Wojcicki said in a statement. “By leveraging the genetic and phenotypic informatio­n provided by consenting 23andme customers and combining it with GSK’S incredible expertise and resources in drug discovery, we believe we can more quickly make treating and curing diseases a reality.”

Glaxo and 23andme say the drug company will use the genetic data to “improve target selection” for “precision” medicines; learn more about genetic “pathways and mechanisms” for disease; and “support identifica­tion of patient subgroups that are more likely to respond to targeted treatments.”

The deal allows Glaxo to extend the relationsh­ip for a fifth year. 23andme says it already has “a portfolio of early stage therapeuti­c research programs across a wide range of disease indication­s that will be assessed for inclusion.”

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