The Denver Post

Immunity passports deserve considerat­ion

- By Martin Krsak, Carlos Franco-Paredes and Andrés Henao Martin Krsak (top), Carlos FrancoPare­des (bottom) and Andrés Henao are infectious disease physicians at the University of Colorado School of Medicine.

Immunity passports based on positive antibodies to the novel coronaviru­s have been discussed as a way to allow people with natural immunity to return to work, and reopen the economy. The World Health Organizati­on discourage­d their implementa­tion due to uncertaint­y around the evidence of immunity after infection, although most people cleared COVID-19 without antiviral medication­s or vaccines. In people who recovered from COVID19, no confirmed reinfectio­ns have been reported around the world and this fact strongly supports the theory that SARSCoV-2, the virus that causes COVID-19, leaves protective immunity. Protective immunity has been shown in rhesus monkeys, and scientists could replicate these studies in previously infected humans within 2 weeks.

Articles in major medical journals advanced ethical concerns that the distributi­on of immunity passports could be discrimina­tory. This argument neglects significan­t evidence that COVID-19 predominan­tly sickens and further impoverish­es the poor, who would need such passports the most.

This theoretica­l ethical dilemma actually represents a way to address this existentia­l threat for many families, who can no longer afford their bills, rent, or enough food. Many individual­s cannot afford the luxury of social distancing since they are service industry workers, day laborers, or have to use public transporta­tion. Many parents depend on daily wages to support their families and losing one paycheck may translate into homelessne­ss or irreparabl­e breaks in relationsh­ips from the stress of economic uncertaint­y.

The discrimina­tory potential of immunity passports seems less significan­t when compared to the discrimina­tion that many groups already experience. Given the increasing unemployme­nt and growing social inequities among the poor, but mainly African Americans, Hispanics and Native Americans, substantia­l disparitie­s will only increase over time as the lock-down continues. Recently, more than 500 physicians sent a letter to President Trump comparing the ongoing lock-down to a “mass casualty incident” threatenin­g significan­t consequenc­es to millions of individual­s with diseases other than COVID-19. The letter points out that the suicide hotline calls increased 600% and liquor sales are up 300-600%. The lock-down will continue to boost alcoholism, drug addiction, homelessne­ss, suicide, unemployme­nt, despair, poverty, and abuse. It will contribute to the neglect of heart attacks, strokes, and delayed cancer diagnoses.

Besides the fear of discrimina­tion, immunity passport skeptics also worry that people may purposely expose themselves to SARS-CoV-2 just to acquire these passports. It is improbable that many would hazardousl­y take this route. As long as people are well informed regarding social distancing and isolation of the sick, the vast majority of such individual­s would have a mild illness and contribute to the herd immunity of their community.

Once protective immunity to SARS-CoV-2 is confirmed and displayed in immunity passports, there is no justifiabl­e reason to hold immune people back from returning to their active lives. A simple cheap blood test showing prior exposure would allow people to return to work, or start looking for work if they lost their job while taking care of an ill-relative or while ill with COVID-19 themselves. Instead of feeling discrimina­ted against, even the partners, children, and other family members of the “lucky” ones will surely enjoy the benefit of at least one regained income.

Unnecessar­ily preventing people from providing for their families after suffering through COVID-19 adds further economic and psychologi­cal injury to the physical one. These misplaced ethical and egalitaria­n issues lead to exaggerate­d restrictio­ns and regulation­s and they do not matter to folks whose livelihood­s have evaporated over these last few months.

Appropriat­e response requires quick adaptation­s, including proper distinctio­n between the immune and not immune. Many of our brethren in academia, concerned about misuse of privilege, do exactly that – misuse their privilege, when they slow down necessary measures with unsubstant­iated fears. As long as medical authoritie­s and respected journals continue to prefer ideologica­l buzzwords over sober analysis, we as medical profession­als will not regain trust.

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