The Denver Post

We can and should trust the COVID- 19 vaccine

- By Krista Kafer Krista L. Kafer is a weekly Denver Post columnist. Follow her on Twitter: @ kristakafe­r..

Ilike to shoot up. A vaccine or two that is. Over the past couple of years, I’ve been vaccinated for hepatitis A and B, meningitis, typhoid, measles, mumps and rubella ( make- up shot for one I missed as a kid), influenza, yellow fever, and tetanus. I don’t want a deadly disease for a souvenir when I travel abroad. I don’t want to pass it on either.

Not only do these vaccinatio­ns protect me and those around me from diseases, they help create community- level immunity that protects medically vulnerable people from infection. Vaccines are the most effective and safe method we have to fight deadly diseases.

That’s why I’ll be in line at the pharmacy when a Food and Drug Administra­tion- approved vaccine for COVID- 19 is available. Unfortunat­ely, only 46% of Coloradans share my enthusiasm. According to a recent Colorado Health Foundation poll, 46% of those surveyed said they were “very likely” to get vaccinated for

COVID- 19. Another 19% replied “somewhat likely.”

Some Americans are skeptical about the release of a COVID- 19 vaccine because they believe the expedited and politicize­d approval process might compromise its safety. Other Americans have lost faith in government institutio­ns because of inconsiste­ncies in reporting and arbitrary and costly pandemic mandates. The use of drones, narc lines, and tracking apps by some authoritie­s has deepened suspicions and created fertile ground for conspiracy theories.

While skepticism is understand­able, Americans need not place their faith in individual­s who are the face of the pandemic response. They can trust the incentives faced by America’s medical research community. In addition to wanting to save lives, which is one of the main reasons people go into medicine, the research community and pharmaceut­ical industry have reputation­s and stock prices on the line. Nobody wants to be the next Theranos, the next Elizabeth Holmes. Secondly, vaccines must complete FDA required animal and human trials for safety and efficacy. As long as the data are transparen­t and available for analysis, critics and competitor­s can challenge it. No human endeavor is perfect, but good incentives help keep people honest.

We can trust the process. We must. A COVID- 19 vaccinatio­n is the only way to end the pandemic, save lives, and restore normalcy. Americans should volunteer with the same zeal they did for the polio vaccine.

Without widespread vaccinatio­n, COVID- 19 will continue to infect and kill people and negatively impact the economy and our way of life. “For COVID- 19, which has an estimated infection fatality ratio of 0.3– 1.3%, the cost of reaching herd immunity through natural infection would be very high, especially in the absence of improved patient management and without optimal shielding of individual­s at risk of severe complicati­ons,” write researcher­s Arnaud Fontanet and Simon Cauchemez in the journal Nature Reviews Immunology.

Herd immunity for most infectious diseases occurs when 70 to 90 percent of the population has achieved immunity through immunizati­on or infection. For a highly contagious disease like measles, 93 percent of the population must be immune to prevent an outbreak. The herd immunity threshold for COVID- 19 is likely to be lower. Fontanet and Cauchemez predict that achieving an optimistic herd immunity of 50 percent through infection alone will mean a half a million or more Americans will die in the process. In other words, without a vaccine there is no way to end the pandemic without an unacceptab­le loss of life.

Although I’m relatively young and in good health and am likely to survive COVID- 19 like several friends have, I pray for a vaccine. I will get that vaccine not just to spare myself the risk of COVID- 19 complicati­ons but for the sake of others who cannot afford such a risk.

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