The Denver Post

Experts say new ideas needed to lower fentayl use and deaths

- By Elise Schmelzer

Colorado lawmakers want to stop the overdose deaths: the toddler who ingested fentanyl, the five friends who thought they were using other drugs, the teen who overdosed in her high school classroom.

As the drug overdose crisis reaches its worse point in years, a bipartisan group of state lawmakers introduced a bill March 25 that attempts to address fentanyl’s exponentia­lly rising death toll.

But what do experts and drug research tell us are the most effective ways to stop this crisis?

Experts interviewe­d by The Denver Post said lawmakers and law enforcemen­t need to think outside of the box when addressing fentanyl. The drug’s potency and the ease with which it can be made mean many tenets of mainstream drug enforcemen­t policy won’t work, they said.

“Tackling this problem is going to require a lot of new ideas,” said Bryce Pardo, associate director of the Drug Policy Research Center at the RAND Corporatio­n.

The bill introduced in the statehouse tackles the issue from both the criminal and harm- reduction angles.

The bill includes harsher penalties for people dealing fentanyl, a new criminal charge for distributi­on resulting in death and increased funding for overdose reversal medication, fentanyl testing strips and medication­assisted treatment in jails.

The bill has sparked criticism from law enforcemen­t and harm reduction advocates alike.

Law enforcemen­t officials want lawmakers to reverse a 2019 bipartisan bill that made possession of up to 4 grams of fentanyl a misdemeano­r crime and make possession of any amount of fentanyl a felony.

Harm reduction and criminal justice reform advocates oppose creating harsher penalties for drug crimes, citing research that longer prison sentences do not reduce overdose deaths.

Here’s what people need to know about fentanyl and how to best minimize drug use and overdose deaths, according to experts and academic research.

How is fentanyl different?

Illicitly produced fentanyl is different than other common illegal drugs in ways that make combating it more difficult.

Most illicit fentanyl found in the United States can be traced to drug labs in Mexico and chemical suppliers in China, according to the Drug Enforcemen­t Agency. That means that U. S. law enforcemen­t does not have control over the sources of the drug. Past interventi­ons in internatio­nal drug sources — like the destructio­n of coca fields — are unlikely to work with fentanyl, researcher­s say.

“Today, it is possible to produce small quantities of fentanyl without specialize­d facilities or highly technical skills, allowing many different points of supply to emerge,” according to a 2020 paper by Pardo and University of Maryland professor Peter Reuter published by the Brookings Institute. “Therefore, the focus on production and traffickin­g of fentanyl are unlikely to generate a lasting disruption.”

A report by the congressio­nally convened Commission on Combating Synthetic Opioid Traffickin­g found that only 3 to 5 metric tons of pure fentanyl would satisfy the entire annual U. S. consumptio­n of illegally supplied opioids. That’s a fraction of the estimated 47 metric tons of heroin and 145 metric tons of cocaine consumed in the country in 2016. The smaller quantities and higher potency makes moving fentanyl

much easier because smaller amounts can be concealed easily or shipped through the mail.

“This devastatin­g story is not leading to a happy ending. The difficult truth is that there is no easy solution to the synthetic opioid problem,” the commission’s report states. “The supply of illicit fentanyl cannot be permanentl­y stopped through enforcemen­t alone — only temporaril­y disrupted before another cartel, traffickin­g method or analogue steps in to fill the market that addiction creates.”

What are other states doing?

Nearly every state in the U. S. has seen a significan­t increase in the number of overdose deaths in recent years, driven primarily by fentanyl, according to data released in October by the Centers for Disease Control and Prevention.

Lawmakers in other states have introduced or passed bills to address fentanyl. In some states, such as Florida and New Mexico, legislatio­n has focused on decriminal­izing fentanyl test strips, which are considered illegal drug parapherna­lia in some parts of the country. In other states, including Wisconsin and Kentucky, lawmakers passed bills creating harsher penalties for fentanyl distributi­on. Texas lawmakers last year passed a bill that upped the sentence for fentanyl delivery or manufactur­e to a minimum of 10 years and a maximum of life imprisonme­nt.

Other states have advanced promising innovation­s with treatment, said Alaina Mcbournie, a manager with Pew’s substance use prevention and treatment initiative. A program in Rhode Island pairs people hospitaliz­ed after an opioid overdose with someone with lived experience with addiction who can help them navigate the system, she said.

Internatio­nally, the small country of Estonia in northern Europe has dealt with fentanyl for 20 years, Pardo said. Law enforcemen­t busted two major sources of fentanyl in 2017, which temporaril­y disrupted supply, although data shows that many users simply shifted to other synthetic drugs. Estonia’s ability to reduce fentanyl supplies significan­tly may be difficult to replicate in the U. S., however, because it is a significan­tly smaller country with a population of about 1.3 million.

“We’re pretty much stuck with the fentanyl problem,” Pardo said.

How can police most successful­ly combat fentanyl?

Law enforcemen­t has an important role in combating drug use and deaths, researcher­s said.

Police can play a key role in keeping fentanyl out of a local drug market by quickly intervenin­g and arresting those bringing the substance into the community, Pardo said.

Once fentanyl is establishe­d in a market, however, law enforcemen­t’s job becomes much trickier. Investigat­ors should focus their efforts on the people doing the most harm by investigat­ing drug deaths as intensely and quickly as a homicide, Pardo said. It is important that those responsibl­e be held accountabl­e quickly. The message from police should be that they will aggressive­ly target dealers who are irresponsi­ble in their handling of fentanyl and cause death, he said.

Police also should play a public informatio­n role and tell the community when fentanyl is found in seized drugs, Pardo said. Quickly alerting people that police found fentanyl in powder being sold as cocaine, for example, could prompt people who use cocaine to be more careful or test their drugs.

Traditiona­l policing strategy includes driving up drug prices by reducing the supply through arrests and seizures, according to the Brookings Institute paper. That method can disrupt a market temporaril­y if a major supplier is disabled, but case studies show that the market adapts and new suppliers emerge.

“Given that fentanyl can be made from cheap and easily obtained pre- precursors, it is unlikely that traditiona­l law enforcemen­t or regulatory approaches aimed at producers will reduce imports,” the paper states.

Do longer prison sentences for drug charges affect drug use?

Researcher­s say there is little evidence that longer prison sentences for drug crimes prevent drug use.

“This is a natural reaction for society and lawmakers to say, ‘ We want to put the squeeze on this,’ but you can’t arrest your way out of this problem,” Pardo said.

A study by the Pew Charitable Trusts published in 2018 compared states’ rate of imprisonme­nt for drug crimes with three ways to measure drug use — selfreport­ed drug use, drug arrests and overdose deaths — and found no statistica­lly significan­t relationsh­ip between the factors, even when controllin­g for demographi­c variables.

“The findings … reinforce a large body of prior research that cast doubt on the theory that stiffer prison terms deter drug misuse, distributi­on and other drug- law violations,” the report states. “The evidence strongly suggests that policymake­rs should pursue alternativ­e strategies that research shows work better and cost less.”

The severity of possible sentences has less of an impact on dealers’ behavior than the certainty that they’ll be caught, Pardo said, referencin­g a 2013 study.

Research also shows that people leaving incarcerat­ion are 10 to 40 times more likely to die of an opioid overdose than the general population, according to the federal Substance Abuse and Mental Health Administra­tion. Incarcerat­ion of people with addiction — without providing treatment — is extremely dangerous and often leads to worse outcomes for that person, said Dr. Nora Volkow, director of the National Institute on Drug Abuse at the National Institutes of Health.

“While they are in prison or jail, they lose the tolerance they developed but they often have not been treated for the addiction,” she said. “So when they’re released, they relapse. But they have no tolerance, and they overdose and die.”

What solutions do research support?

All three experts said expanding access to medication­assisted treatment, the overdose- reversal medication naloxone and testing strips are effective ways to reduce overdose deaths. Medication- assisted treatment is the use of medication­s that blunt opioid withdrawal symptoms, like methadone, combined with counseling and behavioral therapies.

“Medication­s for opioid use disorders are the most effective interventi­on that we currently have,” Volkow said.

Treatment needs to be available in jails, prisons and other criminal justice settings, Volkow said. Thirtyeigh­t of the 54 jails in Colorado offer medication- assisted treatment, according to the Colorado Office of Behavioral Health. The state Department of Correction­s offers medication- assisted treatment to people who were using the treatment prior to going to prison.

Policy leaders need to make sure treatment is accessible to people with or without insurance and those who use Medicaid, Mcbournie said. The treatment programs also need to be available for people who don’t speak English. National data shows that people struggle to access the programs, she said.

A survey by the Colorado Health Institute found that Coloradans who use drugs or have addiction cited stigma associated with substance use or dependence, the cost of services and inadequate insurance coverage as the primary reasons they couldn’t access treatment.

The congressio­nal committee’s report said leaders must recognize that efforts will be even less effective with fentanyl than with other drugs. The report emphasizes increasing efforts to reduce demand for drugs, including increasing public awareness of synthetic opioids, expanding treatment and preventing fatalities by using harm reduction strategies.

“Failure to intervene in ways that appropriat­ely reduce demand and decrease the risk of fatal overdose will almost certainly result in the deaths of hundreds of thousands more Americans and will imperil the country’s economic and social well- being,” the report states.

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