The Denver Post

Overdose deaths rising

- By Noah Weiland and Margot Sanger-katz

» After a catastroph­ic increase in 2020, deaths from drug overdoses rose again to record-breaking levels in 2021, nearing 108,000, the result of a worsening fentanyl crisis, according to preliminar­y data published Wednesday by the Centers for Disease Control and Prevention.

The increase of nearly 15% followed a much steeper rise of almost 30% in 2020, an unrelentin­g crisis that has consumed federal and state drug policy officials. Since the 1970s, the number of drug overdose deaths has increased every year except 2018.

A growing share of deaths continue to come from overdoses involving fentanyl, a class of potent synthetic opioids that are often mixed with other drugs, and methamphet­amine, a synthetic stimulant. State health officials battling an influx of both drugs said many of the deaths appeared to be the result of combining the two.

Drug overdoses, which long ago surged above the country’s peak deaths from AIDS, car crashes and guns, killed about one-quarter as many Americans last year as COVID-19.

Deaths involving synthetic opioids — largely fentanyl — rose to 71,000 from 58,000, while those associated with stimulants such as methamphet­amine, which has grown cheaper and more lethal in recent years, increased to 33,000 from 25,000. Because fentanyl is a white powder, it can be combined easily with other drugs, including opioids such as heroin, and stimulants including meth and cocaine, and can be stamped into counterfei­t pills for anti-anxiety drugs such as Xanax. Such mixtures can prove lethal if drug users are unaware they are taking fentanyl or are unsure of the dose.

Deaths from both classes of drugs have been rising in recent years.

But there is growing evidence that mixing stimulants and opioids — into combinatio­ns known as “speedballs” and “goofballs” — is becoming more common, too. Dan Ciccarone, a professor of family and community medicine at the University of California-san Francisco, who studies drug markets, has just begun a multiyear study of the combinatio­n of opioids and meth.

“There’s an intertwine­d synthetics epidemic the likes of which we’ve never seen,” he said. “We’ve never seen a powerful opioid such as fentanyl being mixed with such a potent methamphet­amine.”

The numbers released Wednesday are considered provisiona­l and may change as the government reviews more death records. But they showed that a crisis that escalated sharply during the first year of the pandemic does not appear to be letting up.

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