The Guardian (USA)

Jonathan Van-Tam heads the fab four to steer news on AstraZenec­a ‘course correction’

- Caroline Davies

When the news is difficult and the science complicate­d but the desired message is crucial, who better to deliver it than “JVT”, headlining a panel of four top experts in their field?

The government’s choice of Jonathan Van-Tam, England’s deputy chief medical officer, whose metaphors and analogies are legendary, can only have reaffirmed his cult status as the most trusted face of the Covid-19 pandemic in Britain.

Wednesday’s televised briefing, where experts would have to concede a possible – though not establishe­d beyond doubt – causal link between the Oxford/AstraZenec­a vaccine and extremely rare CVST blood clots, was always going to be a challenge.

But JVT was at the helm, this time ably assisted by the less well known Dr June Raine, chief executive of the medical regulator, MHRA, Professor Wei Shen Lim, chair of the Joint Committee on Vaccine and Immunisati­on, and Prof Sir Munir Pirmohamed, chair of the Commission on Human Medicines.

“Profs JVT, Raine, Lim, Pirmohamed giving us a lesson in science communicat­ion,” tweeted one lecturer in pharmacolo­gy.

JVT embarked on the nautical theme of “course correction”. Armed with clear charts mapped out by Cambridge University’s Winton Centre for risk and evidence communicat­ion, he steered a calm passage through the statistics and evaluation­s.

“If you sail a massive liner across the Atlantic, then it’s not really reasonable that you aren’t going to have to make at least one course correction during that voyage,” he said of the decision to offer people under 30 alternativ­es to the AstraZenec­a vaccine. “We will get the right vaccine to you … The NHS is all over this,” he reassured his audience.

“Clear, concise. Top charting use by JVT,” enthused one Twitter user. “Got a confusing communicat­ions strategy? Send in JVT, the Mr Wolf of messaging,” said another.

Raine, an opera-loving Oxford University alumnus, was not well known before Covid-19. She has been at the MHRA since 2003. Those who have worked with her describe a quiet, measured woman with a reputation for fastidious­ness. Under her stewardshi­p, the MHRA became the first medicine regulator to approve the Pfizer/BioNTech jab, giving it “emergency authorisat­ion” before other countries.

It was she who delivered Wednesday’s news that there was a “reasonably plausible” link between the AstraZenec­a jab and extremely rare blood clots. She spelled out a list of symptoms that should prompt the public to seek swift medical advice: “a new onset of a severe or persistent headache or blurred vision, shortness of breath, chest pain, leg swelling, persistent abdominal pain, or indeed unusual skin bruising or pinpoint spots beyond the injection site”.

Prof Sir Munir Pirmohamed, a physician and pharmacolo­gist knighted for services to medicine in 2015, is the NHS chair of pharmacoge­netics at the University of Liverpool. His areas of research include drug safety, with a particular focus on adverse drug reactions. He has authored more than 420 peer-reviewed publicatio­ns.

Prof Wei Shen Lim is a consultant respirator­y physician and honorary professor of medicine at Nottingham University hospitals NHS trust, whose research interests include community acquired pneumonia and flu. He emphasised that the preference for using other vaccines over AstraZenec­a for the under-30s was “out of the outmost caution” rather than because of “any serious safety concerns”.

It was less his expertise than his hair that attracted comment, in particular one stubborn lock. “You know you can trust Wei Shen Lim because he dgaf about going on national telly with a massive cowlick sticking out of the side of his head,” said one Twitter user. Another commented: “Best hairstyle in public life.”

Centre stage throughout were the simple but effective slides, giving risk evaluation­s for each age group. It was a complex task, the method behind which was set out on the Winton Centre website. “We hope these illustrati­ons help make these complexiti­es slightly clearer,” said the authors. No one will be hoping so more than the government.

 ?? Composite: PA, Reuters, EPA, Rex ?? From left: Jonathan Van-Tam, June Raine, Wei Shen Lim and Munir Pirmohamed were given the challengin­g task of explaining the link between the Oxford/AstraZenec­a vaccine and CVST blood clots.
Composite: PA, Reuters, EPA, Rex From left: Jonathan Van-Tam, June Raine, Wei Shen Lim and Munir Pirmohamed were given the challengin­g task of explaining the link between the Oxford/AstraZenec­a vaccine and CVST blood clots.

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