The Mercury News

Google is training machines to predict when a patient will die

- By Mark Bergen

A woman with late-stage breast cancer came to a city hospital, fluids already flooding her lungs. She saw two doctors and got a radiology scan. The hospital’s computers read her vital signs and estimated a 9.3 percent chance she would die during her stay.

Then came Google’s turn. A new type of algorithm created by the company read up on the woman — 175,639 data points — and rendered its assessment of her death risk: 19.9 percent. She passed away in a matter of days.

The harrowing account of the unidentifi­ed woman’s death was published by Google in May in research highlighti­ng the healthcare potential of neural networks, a form of artificial intelligen­ce software that’s particular­ly good at using data to automatica­lly learn and improve. Google had created a tool that could forecast a host of patient outcomes, including how long people may stay in hospitals, their odds of readmissio­n and chances they will soon die.

What impressed medical experts most was Google’s ability to sift through data previously out of reach: notes buried in PDFs or scribbled on old charts. The neural net gobbled up all this

unruly informatio­n then spat out prediction­s. And it did it far faster and more accurately than existing techniques. Google’s system even showed which records led it to conclusion­s.

Hospitals, doctors and other health care providers have been trying for years to better use stockpiles of electronic health records and patient data. More informatio­n shared and highlighte­d at the right time could save lives — and at the very least help medical workers spend less time on paperwork and more time on care. But current methods of mining health data are costly, cumbersome and time consuming.

As much as 80 percent of the time spent on today’s predictive models goes to the “scut work” of making the data presentabl­e, said Nigam Shah, an associate professor at Stanford University, who co-authored Google’s research paper, published in the journal Nature. Google’s approach avoids this. “You can throw in the kitchen

sink and not have to worry about it,” Shah said.

Google’s next step is moving this predictive system into clinics, AI chief Jeff Dean told Bloomberg News in May. Dean’s health research unit — sometimes referred to as Medical Brain — is working on a slew of AI tools that can predict symptoms and disease with a level of accuracy that is being met with hope as well as alarm.

Inside the company, there’s a lot of excitement about the initiative. “They’ve finally found a new applicatio­n for AI that has commercial promise,” one Googler says. Since Alphabet’s Google declared itself an “AI-first” company in 2016, much of its work in this area has gone to improve existing internet services. The advances coming from the Medical Brain team give Google the chance to break into a brand new market — something co-founders Larry Page and Sergey Brin have tried over and over again.

Software in health care is largely coded by hand these days. In contrast, Google’s approach, where machines learn to parse data on their own, “can just leapfrog everything else,” said Vik Bajaj,

a former executive at Verily, an Alphabet health-care arm, and managing director of investment firm Foresite Capital. “They understand what problems are worth solving,” he said.

Dean envisions the AI system steering doctors toward certain medication­s and diagnoses. Another Google researcher said existing models miss obvious medical events, including whether a patient had prior surgery. The person described existing hand-coded models as “an obvious, gigantic roadblock” in health care. The person asked not to be identified discussing work in progress.

For all the optimism over Google’s potential, harnessing AI to improve healthcare outcomes remains a huge challenge. Other companies, notably IBM’s Watson unit, have tried to apply AI to medicine but have had limited success integratin­g the technology into reimbursem­ent systems.

Google has long sought access to digital medical records, also with mixed results. For its recent research, the internet giant cut deals with the University of California, San Francisco, and

the University of Chicago for 46 billion pieces of anonymous patient data. Google’s AI system created predictive models for each hospital, not one that parses data across the two, a harder problem. Google is working to secure new partners for access to more records.

A deeper dive into health would only add to the vast amounts of informatio­n Google already has on us. “Companies like Google and other tech giants are going to have a unique, almost monopolist­ic, ability to capitalize on all the data we generate,” said Andrew Burt, chief privacy officer for data company Immuta. He and pediatric oncologist Samuel Volchenbou­m wrote a column arguing government­s should prevent this data from becoming “the province of only a few companies.”

Google is treading carefully when it comes to patient informatio­n, particular­ly as public scrutiny over data-collection rises. Last year, British regulators slapped DeepMind, another Alphabet AI lab, for testing an app that analyzed public medical records without telling patients that their informatio­n would be used like

this. With the latest study, Google and its hospital partners insist their data is anonymous, secure and used with patient permission. Volchenbou­m said the company may have a more difficult time maintainin­g that data rigor if it expands to smaller hospitals and networks.

Still, Volchenbou­m believes these algorithms could save lives and money. He hopes health records will be mixed with a sea of other stats. Eventually, AI models could include informatio­n on local weather and traffic — other factors that influence patient outcomes. “It’s almost like the hospital is an organism,” he said.

Few companies are better poised to analyze this organism than Google. The company and its Alphabet cousin, Verily, are developing devices to track far more biological signals. Even if consumers don’t take up wearable health trackers en masse, Google has plenty of other data wells to tap. Google’s Android phones track things like how people walk, valuable informatio­n for measuring some ailments. All that could be thrown into the medical algorithmi­c soup.

Medical records are just part of Google’s AI health care plans. Its Medical Brain has unfurled AI systems for radiology, cardiology and even dermatolog­y. Staff created an app for spotting malignant skin lesions.

Dean, the AI boss, stresses this experiment­ation relies on serious medical counsel. Google is starting a new trial in India that uses its AI software to screen images of eyes for early signs of a condition called diabetic retinopath­y. Before releasing it, Google had three retinal specialist­s furiously debate the research results, Dean said.

Over time, Google could license these systems to clinics, or sell them through the company’s cloud-computing division as a sort of diagnostic­s-as-a-service. Microsoft, a top cloud rival, is also working on predictive AI services. To commercial­ize an offering, Google would first need to get its hands on more records. Google could buy them, but that may not sit as well with regulators or consumers. The deals with UCSF and the University of Chicago aren’t commercial.

For now, the company says it’s too early to settle on a business model.

 ?? MATTHEW LLOYD — BLOOMBERG NEWS ?? Google is designing AI systems to examine medical records and data on everything from radiology to dermatolog­y to predict patient outcomes.
MATTHEW LLOYD — BLOOMBERG NEWS Google is designing AI systems to examine medical records and data on everything from radiology to dermatolog­y to predict patient outcomes.

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