The Mercury News

How intellectu­al property rights helped America fight COVID-19

- By James Pooley James Pooley is a former deputy director general of the World Intellectu­al Property Organizati­on and a member of the Center for Intellectu­al Property Understand­ing.

When COVID-19 came ashore, glaring gaps in the government’s pandemic preparedne­ss became painfully obvious. Everything from inadequate stockpiles of personal protective equipment to confusing and uncoordina­ted guidance regarding closures hampered our early response.

But while the government floundered, America’s research scientists sprang into action. Moderna actually invented its vaccine mere weeks after the virus was geneticall­y sequenced in January — though of course, it took months of clinical trials to prove the vaccine was safe and 94% effective.

Now, tens of millions of Americans have been vaccinated, and the end of the pandemic is in sight. The credit belongs to strong intellectu­al property protection­s, as they enabled scientists to move quickly and raise ample funding for vaccine research.

As a post-pandemic world nears — and we begin to prepare for future pandemics — bolstering America’s intellectu­al property infrastruc­ture will help equip us for whatever challenges lie ahead.

Decades of expensive and risky research projects have paved the way for today’s breakthrou­ghs. Over the last 10 years alone, drug companies invested more than $1.5 trillion on global pharmaceut­ical research. And some of that went toward developing the technologi­es underpinni­ng the leading COVID-19 vaccines.

Notably, that includes MRNA technology. Messenger RNA, or MRNA, directs our bodies to produce proteins. And for nearly three decades, researcher­s have posited that they could use synthetic MRNA to guide the production of proteins that help treat specific diseases.

When COVID-19 started spreading, pharmaceut­ical company researcher­s were actively working on MRNA vaccines for the flu, rabies and Zika. The pandemic necessitat­ed a shift in priorities — and within weeks, Moderna, a small biotech in Massachuse­tts, and Biontech, a small biotech in Germany that had partnered with Pfizer a few years prior, began working on MRNA vaccines that essentiall­y instruct cells to create a harmless version of the “spike” protein found on the surface of the coronaviru­s.

This, in turn, triggers an immune response, which produces antibodies and teaches our body how to fight off future infection. The Food and Drug Administra­tion granted emergency use authorizat­ion to the MRNA vaccines from Biontech/pfizer and Moderna in December.

The fight against deadly diseases won’t end with COVID-19, of course.

Fortunatel­y for us, America remains at the forefront of the global biopharmac­eutical landscape. America is home to less than 5% of the world’s population but roughly half of all internatio­nal pharmaceut­ical R&D spending.

That’s largely because of strong intellectu­al property protection­s. These protection­s, including patents, give innovators a fair opportunit­y to recoup their investment costs before generics firms can manufactur­e copycat medicines. It takes years to develop a new medicine, conduct clinical studies and navigate regulatory review. And it costs $2.6 billion, on average, to bring a new drug to market.

Patent protection­s make it possible for companies to chase stateof-the-art ideas. Ultimately, if a drugmaker wants to stay in business, it’s imperative they manufactur­e innovative products that provide considerab­le benefit to patients. Those are the types of products that end up changing the world for the better — just like MRNA vaccines are doing right now.

Yet, inexplicab­ly, some have proposed weakening — or outright dismantlin­g — these critical protection­s. On the home front, these attacks have come from Sen. Bernie Sanders, I-VT., and Rep. Jan Schakowsky, D-ill.

It’s not an accident that the overwhelmi­ng majority of drugs are developed in countries with strong intellectu­al property rights. Quite simply, there would be no COVID-19 vaccines without them. America’s pharmaceut­ical companies delivered the greatest breakthrou­ghs in modern history precisely because our ecosystem incentiviz­es firms to pursue cutting-edge research.

When the next pandemic arrives, we will have no hope of defeating it if we weaken the one industry that’s best prepared to develop innovative treatments.

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