The battle for weight loss continues

DEAR DR. ROACH>> I am looking for advice on diet pills.

I have tried everything. I eat well, go to the gym and walk, but my meniscus problem limits my walking speed. Since menopause, I have gained 30 pounds.

I am sure there is something out there that will kick-start my metabolism. I am so depressed, and my doctor has no sympathy. — A.R. ANSWER>> Difficulty losing excess weight is one of the greatest public health problems in industrial countries, and I’m not going to solve it here, but I’ll try to discuss principles of drug treatment.

One critical issue is to look at any medications you are taking: Many can cause weight gain, and some, like beta blockers, often used for high blood pressure, are unrecognized by many doctors. Stopping medicines that predispose to weight gain is critical.

Depression itself is a predisposing factor to weight gain. Some people lose weight with depression, but my experience is that weight gain is much more common. Many antidepression medicines cause weight gain. One, bupropion, commonly causes weight loss.

Among medicines specifically for weight loss, most work either by decreasing fat absorption or by reducing appetite. They don’t really increase metabolism, with the exception of phentermine, which does increase resting energy expenditure somewhat and may be useful in preventing weight regain in people who have lost weight, for whom metabolism does often slow down.

Orlistat (called Xenical by prescription, Alli over-the-counter) prevents the body from absorbing some of the fat in the diet. The fat is then excreted through stool. This may cause many people to have gastrointestinal side effects, which are diminished when on a low-fat diet. Orlistat caused people to lose about 7 pounds more than placebo.

There are several drugs that work on appetite. Liraglutide is a diabetes medicine that has been found to be helpful in overweight people even without diabetes. Metformin is another diabetes medicine that is sometimes used for weight loss, although it does not have a Food and Drug Administration indication for this. Both of these diabetes drugs often have gastrointestinal side effects. Lorcaserin (Belviq) is about as effective as orlistat, but with fewer side effects (headache was the most common).

Some weight loss experts use combination drugs, including phentermine/topiramate (Qsymia) and bupropion/naltrexone (Contrave). These have more significant risks.