Our deadliest drug is in focus

For the first time in a while, pundits and politicians were talking about the drug that kills more people than any other each year in the U.S.

I’m talking about alcohol, which upstaged opioid abuse in news coverage recently, but only after Rear Adm. Ronny L. Jackson withdrew his name for consideration to head Veterans Affairs, in part because of allegations that he has abused alcohol. Jackson has denied any problem with alcohol.

This provides an opportune time to discuss the seriousness of alcohol abuse.

Alcohol contributes to 88,000 deaths in the U.S. each year, more than double the number of people, 42,000, killed by heroin and opioid prescription drug overdose in 2016. Excessive drinking accounted for one in 10 deaths among workingage adults.

In addition, more than 66.7 million Americans reported binge drinking in the past month in 2015, according to a report by the surgeon general.

As someone who has studied alcohol use disorder for over 15 years and who has treated thousands of patients who have it, I think it’s a major, yet often poorly understood, public health problem.

Alcohol can be a quick and easy way to get into the spirit of a celebration. And it feels good. After two glasses of wine, the brain is activated through complex neurobiochemical processes that naturally release dopamine, a neurotransmitter of great importance.

When the dopamine molecule locks on to its receptor located on the surface of a neuron, a “buzz” occurs. It is often anticipated before the second glass is empty.

There are those, however, who drink right past the buzz into intoxication and, often, into trouble. For them, the brain starts releasing the same enjoyable dopamine, no different than what happens in the casual drinker’s, but it doesn’t stop there. A compulsion to binge drink can result.

Binge drinking, defined as drinking five or more drinks for men and four for women on the same occasion, is a medical condition that victimizes the comparative malfunction of the pleasure circuits in the brain.

The alcohol addiction process involves a three-stage cycle: binge-intoxication, withdrawalnegative affect, and preoccupation-anticipation.

It begins in the neurons, the basic type of brain cell. The brain has an estimated 86 billion of these cells, which communicate through chemical messengers called neurotransmitters. Neurons can organize in clusters and form networks in order to perform specific functions such as thinking, learning, emotions and memory. The addiction cycle disrupts the normal function of some of these networks in three areas of the brain.

The disruptions do several things that contribute to continued drinking. They enable drinking-associated triggers, or cues, which lead to seeking alcohol. They also reduce the sensitivity of the brain systems, causing a diminished experience of pleasure or reward, and heighten activation of brain stress systems. Last, they reduce function of brain executive control systems, the part of the brain that typically helps make decisions and regulate one’s actions, emotions and impulses.

Because binge drinkers’ brains feel intense pleasure from alcohol, there is a powerful motivation to binge drink again and again. What may begin as social binge drinking at parties for recreation can cause progressive neuro-adaptive changes in brain structure and function. Continued partying can transition into an uncontrollable daily pattern of alcohol use. These maladaptive neurological changes can persist long after alcohol use stops.

During the binge-intoxication stage, the basal ganglia rewards the drinker with pleasurable effects, releasing dopamine, the neurotransmitter responsible for the rewarding effects of alcohol and creating the desire for more.

With continued bingeing, the “habit circuity” is repeatedly activated in another part of the basal ganglia called the dorsal striatum. It contributes to the compulsive seeking of more alcohol. This explains the craving that is triggered when a binge drinker is driving by a favorite bar and can’t resist pulling in, even after a promise to go directly home after work.

After a period of abstinence from alcohol, which may last only hours, the drinker enters the preoccupation-anticipation stage. This involves the prefrontal cortex, where executive decisions are made about whether or not to override the strong urges to drink. This part of the brain functions with a “go system” and “stop system.”

When the go circuits stimulate the habit-response system of the dorsal striatum, the drinker becomes impulsive and seeks a drink, perhaps even subconsciously. The stop system can inhibit the activity of the go system and is important especially in preventing relapse.

Brain imaging studies show that binge drinking can disrupt the function in both the go and stop circuits. This interferes with proper decision-making and behavioral inhibition. The drinker is both impulsive and compulsive.

Scientific evidence shows that this disorder can be treated.

It is important to know that alcohol use disorder is a brain disorder causing a chronic illness. When comprehensive, continuing care is provided, recovery results improve, and the binge drinker has the hope of remaining sober as long as treatment and maintenance of sobriety become a dedicated lifestyle choice.