The Oklahoman

A new COVID-19 challenge: Mutations rise along with cases

- By Marilynn Marchione

The race against the virus t hat causes COVID- 1 9 has taken a new turn: Mutations are rapidly popping up, and the longer it takes to vaccinate people, the more likely it is that a variant that can elude current tests, treatments and vaccines could emerge.

The coronaviru­s is becoming more geneticall­y diverse, and health officials say the high rate of new cases is the main reason. Each new infection gives the virus a chance to mutate as it makes copies of itself, threatenin­g to undo the progress made so far to control the pandemic.

On Friday, the World Health Organizati­on urged more effort to detect new variants. The U.S. Centers for Disease Control and Prevention said a new version first identified in the United Kingdom may become dominant in the U.S. by March. Although it doesn't cause more severe illness, it will lead to more hospitaliz­ations and deaths just because it spreads much more easily, said the CDC, warning of “a new phase of exponentia­l growth.”

“We' re taking it really very seriously,” Dr. Anthony Fauci, the U.S. government's top infectious disease expert, said Sunday on NBC's “Meet the Press.”

“We need to do everything we can now . . . to get transmissi­on as low as we possibly can,” said Harvard University's Dr. Michael Mina. “The best way to prevent mutant strains from emerging is to slow transmissi­on.”

So far, vaccines seem to remain effective, but there are signs that some of the new mutations may undermine tests for the virus and reduce the effectiven­ess of antibody drugs as treatments.

“We' reina race against time” because the virus “may stumble upon a mutation” that makes it more dangerous, said Dr. Pardis Sabeti, an evolutiona­ry biologist at the Broad Institute of MIT and Harvard.

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