The Oneida Daily Dispatch (Oneida, NY)

Drug prices continue rising

- By LindaA. Johnson and Nicky Forster

NEWYORK (AP) » President Donald Trump made reducing drug prices a key promise during his election campaign, repeatedly accusing drugmakers of “getting away with murder.” At the end of May, he promised that drug companies would be announcing “massive” voluntary drug price cuts within two weeks.

That hasn’t happened, and an Associated Press analysis of brand-name prescripti­on drug prices shows it’s been business as usual for drugmakers, with far more price hikes than cuts. The number of increases slowed somewhat and were not quite as steep as in past years, the AP found.

Over the first seven months of the year, there were 96 price hikes for every price cut, the AP found. Health and Human Services Secretary Alex Azar, the administra­tion’s point person for efforts to lower drug prices, conceded in a recent AP interview that it will be a while before drug prices fall. He noted the complexity of the medicine market and its incentives for drugmakers to boost prices so

they and middlemen make bigger profits.

“I amnot counting on the altruism of pharma companies lowering their prices,” said Azar, who was a senior executive in Eli Lilly & Co.’s U.S. business for a decade when it dramatical­ly raised prices for its insulin products

The AP analyzed 26,176 U.S. list price changes for brand-name prescripti­on drugs from Jan. 1 through July 31 in the years 2015 through 2018, using data supplied by health informatio­n analytics firm Elsevier. The AP focused its analysis on the first seven months of each year because of the seasonalit­y of price changes and to make meaningful year - to-year comparison­s.

The data included more than 97 percent of price changes during those periods and, for many drugs, several dosages and drugs forms, such as pills, liquids and injectable drugs. (Inthe 3 percent of cases not analyzed, the AP couldn’t determine how the new price compared with the previous one or whether it was for a product newon themarket.)

Among the AP’s findings: The AP also asked 24 large drug companies this summer if they planned to cut drug prices. None said they did, though some didn’t answer. Drugmakers typically say they need to keep raising prices of existing drugs to pay for costly, lengthy research to develop new medicines, though industry critics dispute that.

Dr. Peter Bach, who heads the Center for Health Policy and Outcomes at Memorial Sloan Kettering Cancer Center in NewYork, said the AP’s analysis shows there’s beenno big move to decrease prices.

“We have a broken pricing system,” he said.

In the U.S., drug pricing is far from transparen­t. Manufactur­ers typically set high list prices but then negotiate rebates and discounts with middlemen, such as prescripti­on benefit managers, to get preferenti­al insurance coverage for their products. Many consumers never see the listprice, though rising drug prices generally put pressure on insurers to raise rates. Patients with high-deductible or no insurance often get stuck being charged the full list price.

Elsevier drug pricing expert Kay Morgan said the data indicate companies are being more cautious about price increases, but Trump’s criticisms are just one factor.

“It’s everyone saying, ‘This has got to stop,’” Morgan said.

She cited frequent media coverage, patients and their advocacy groups pressuring members of Congress to fight high drug prices, and Congress huge include price holding hikes increases. hearings for EpiPen Those on emergency allergy shots and the actions of disgraced former pharma executive Martin Shkreli, who hiked the price of an old infection treatment from$13.50 to $750 per pill overnight. “The rate of increases has slowed down, but prices haven’t decreased,” said Stephen Schondelme­yer, a University of Minnesota professor of pharmaceut­ical economics who runs its research program on drug prices and public policy. He noted such temporary pricing restraint occurs periodical­ly, around elections and other times when the issue is hot, but then companies go back to raising drug prices. Edward Jones drug analyst Ashtyn Evans said, “companies are self-policing more.” She noted many firms are now taking one price hike near 10 percent once a year, instead of two or three smaller hikes each year. “That started before Trump was even elected,” she said. Pfizer, the biggest U.S. drugmaker, angered Trump by raising prices on July 1 for 40 medicines and vaccines, totaling more than 100 products, with some increases hitting 9 percent. Pfizer had already hiked list prices in January for all but twoof those medicines, most by 9 percent to 9.5 percent, according to Elsevier’s data. “Pfizer & others should be ashamed that they have raised drug prices for no reason. ... We will respond!” Trump tweeted . After a call with Trump, Pfizer executives reversed those price hikes until January at the latest.

Seven other major drugmakers, perhaps hoping to avoid their own Twitter spanking by Trump, have since said they wouldn’t increase prices for the rest of the year. All of them had already taken price hikes on many of their products in January.

Meanwhile, 77 percent of Americans consider U.S. prescripti­on drug costs “unreasonab­le” and fewer than a quarter approve of how Trump is addressing the problem, according to amid August national poll of 1,002 adults from West Health Institute, a nonpartisa­n health care research group.

Just this month, a fresh controvers­y over price hikes erupted, triggering criticism of Nostrum Laboratori­es. The tiny Kansas City, Missouri-based generic drug company posted a 404 percent increase, to $2,392.32 per bottle, for its generic version of a 65-year-old liquid antibiotic for bladder infections, nitrofuran­toin.

Nostrum’s product and competitor­s hadbeenoff the market since January after federal regulators required that they be reformulat­ed. Nostrum now is relaunchin­g its version amid limited competitio­n. Chief executive Nirmal Mulye told the AP that the maker of the brand-name version, Casper Pharma, hiked its price to

—There were fewer price increases this year from January through July than in comparable prior-year

periods, but companies still hiked prices far more often than they cut them. This year through the end of July, there were 4,412 brand-name drug price increases and 46 price cuts,

a ratio of 96-to-1.

—In June and July, right

after Trump’s price cut prediction, there were 395

price increases and 24 decreases. The two dozen cuts were up from the 15 decreases in those same two months last year, but

increases still outpaced decreases by a ratio of 16.5

to-1.

—The median price increase, meaning half were higher and half lower, was 5.2 percent in June and July of 2018, down from 8 percent in that

period in 2017.

—The median price cut this June and July was 11 percent, much smaller than in comparable periods in

prior years.

$2,800, so Nostrum was “obligated” to maximize its own profit to keep the company afloat after years of losing money.

Experts don’t expect drugmakers to slash prices soon, if ever.

Trump’s “blueprint” for reducing drug prices, released on May 10, has no provisions for reducing prices of the costliest new brand-name drugs, which won’t face competitio­n for years, Bach said.

Schondelme­yer predicts drugmakers “will wait to see if this blueprint is going to do anything.” If it doesn’t bring substantiv­e policy changes, they won’t alter their pricing strategy, he said.

Azar acknowledg­ed there’s no “overnight solution,” but he said the administra­tion is making progress on blueprint proposals like increasing generic competitio­n for old drugs and giving government prescripti­on programs more negotiatin­g power.

 ?? MARY ALTAFFER— ASSOCIATED PRESS ?? Health & Human Services Secretary Alex Azar speaks during an interview with The Associated Pressin New York.
MARY ALTAFFER— ASSOCIATED PRESS Health & Human Services Secretary Alex Azar speaks during an interview with The Associated Pressin New York.
 ??  ?? Chart shows the price increases count and price decreases count from January 1st to July 31st for 2015, 2016, 2017 and 2018.
Chart shows the price increases count and price decreases count from January 1st to July 31st for 2015, 2016, 2017 and 2018.
 ??  ?? Chart shows monthly counts of drug price increases from January 2015to July 2018.
Chart shows monthly counts of drug price increases from January 2015to July 2018.
 ??  ?? Chart shows price changes for Pfizer drugs Viagra and Lyrica from 2015to 2018.
Chart shows price changes for Pfizer drugs Viagra and Lyrica from 2015to 2018.
 ?? MARY ALTAFFER—ASSOCIATED PRESS ?? In this Wednesday, Sept. 12, 2018, photo Health & Human Services Secretary Alex Azar smiles during an interview with The Associated Pressin New York. Azar the administra­tion’s point person for efforts to lower drug prices, conceded in a recent AP interview that it will be a while before drug prices fall.
MARY ALTAFFER—ASSOCIATED PRESS In this Wednesday, Sept. 12, 2018, photo Health & Human Services Secretary Alex Azar smiles during an interview with The Associated Pressin New York. Azar the administra­tion’s point person for efforts to lower drug prices, conceded in a recent AP interview that it will be a while before drug prices fall.

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