The Reporter (Lansdale, PA)

HOW COVID-19 ATTACKS

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On average, a person who develops symptoms will feel ill for about seven days after their onset.

Typically, COVID-19 is a respirator­y disease that is most harmful to the lungs. The virus enters the body through the nose, mouth or eyes, then invades the lungs.

SARS-CoV-2 can damage cilia, the hairlike projection­s on cells that move the protective mucus layer containing debris and microbes upward from the lungs to be expelled through the mouth and nose.

When the cells' lining in the respirator­y tract gets infected, that lining can be breached by bacteria that cause pneumonia. In addition, that breach can alert the immune system to overreact, causing inflammato­ry responses that damage the lungs further.

Inflammati­on causes fluid buildup that impedes the movement of oxygen to the bloodstrea­m. Troubled breathing can occur around five days after infection. Moderate to severe cases can involve pneumonia; recovery can take weeks. Hospital ventilator­s can provide oxygen under pressure, which helps push it through to the bloodstrea­m.

Severe cases can advance to acute respirator­y distress syndrome, or ARDS, characteri­zed by fluid buildup in the lungs that prevents oxygen from reaching the blood.

The inflammati­on driving ARDS also triggers a flood of immune cells that start killing healthy tissue, leading to scar formation in the lungs that further impedes oxygen's movements to the blood.

Thus, the cause of most COVID-19 deaths is ARDS, in which the lungs become so fluid-filled, stiff and scarred that they can no longer provide oxygen to the bloodstrea­m.

Nano test answer: about 11.6 days

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