Simple exercise may help aging brain, study hints
New research hints that even a simple exercise routine just might help older Americans with mild memory problems.
Doctors have long advised physical activity to help keep a healthy brain fit. But the governmentfunded study marks the longest test of whether exercise makes any difference once memory starts to slide — research performed amid a pandemic that added isolation to the list of risks to participants’ brain health.
Researchers recruited about 300 sedentary older adults with hard-to-spot memory changes called mild cognitive impairment or MCI — a condition that’s sometimes, but not always, a precursor to Alzheimer’s. Half were assigned aerobic exercises and the rest stretching-and-balance moves that only modestly raised their heart rate.
Another key component: Participants in both groups were showered with attention by trainers who worked with them at YMCAs around the country — and when COVID-19 shut down gyms, helped them keep moving at home via video calls.
After a year, cognitive testing showed overall neither group had worsened, said lead researcher Laura Baker, a neuroscientist at Wake Forest School of Medicine. Nor did brain scans show the shrinkage that accompanies worsening memory problems, she said.
By comparison, similar MCI patients in another long-term study of brain health — but without exercise — experienced significant cognitive decline over a year.
Those early findings are surprising, and the National Institute on Aging cautioned that tracking non-exercisers in the same study would have offered better proof.
But the results suggest “this is doable for everybody” — not just seniors healthy enough to work up a hard sweat, said Baker, who presented the data Tuesday at the Alzheimer’s Association International Conference. “Exercise needs to be part of the prevention strategies” for at-risk seniors.
Previous research has found regular physical activity of any sort may reduce damaging inflammation and increase blood flow to the brain, said Alzheimer’s Association chief scientific officer Maria Carrillo.
But the new study is especially intriguing because the pandemic hit halfway through, leaving already vulnerable seniors socially isolated — something long known to increase people’s risk of memory problems, Carrillo said.
It’s a frustrating time for dementia research. Doctors are hesitant to prescribe a high-priced new drug called Aduhelm that was supposed to be the first to slow progression of Alzheimer’s — but it’s not yet clear if it really helps patients. Researchers last month reported another drug that works similarly — by targeting amyloid plaques that are an Alzheimer’s hallmark — failed in a key study.
While amyloid clearly plays a role, it’s important that drugmakers increasingly are targeting many other factors that can lead to dementia, Carrillo said, because effective treatment or prevention likely will require a combination of customized strategies.
One example of a new approach: Sometimes in dementia, the brain has trouble processing blood sugar and fats for the energy it needs, John Didsbury of T3D Therapeutics told the Alzheimer’s meeting. His company is testing a pill that aims to rev up that metabolism, with results expected next year.