GIANTS GAMEDAY

The Game: Giants (1-3) at Panthers (2-1), Bank of America Stadium, Sunday 1 p.m. ET (FOX)

The Line: Carolina by 7

History: The Giants lead the all-time series dating back to 1996, 6-4. Carolina has won the last two matchups including the last game at Bank of America Stadium in 2013.

Key Matchups

Giants QB Eli Manning vs. Panthers’ pass defense: Manning is completing a career-high 74 percent of his passes but is averaging only 6.99 yards per attempt. Carolina is allowing the 12th-fewest passing yards per game (247) with 12 plays of 20+ yards in three games. Giants C John Greco vs. Panthers LB Luke Kuechly: Carolina’s five-time Pro Bowl middle linebacker is flying all around the field again this season with 26 tackles, one interception and one pass defended. Whenever he blitzes Sunday, Greco will need to do a good job of diagnosing the pressure and reacting accordingly to keep Manning upright. Giants LB Alec Ogletree vs. Panthers QB Cam Newton — New York has plenty experience against the zone read this season, with Sunday marking the toughest challenge yet. Ogletree, the defense’s captain in the middle, will be key to containing Newton in the running game. Giants CB Janoris Jenkins vs. Panthers WR Devin Funchess: With Carolina looking for secondary weapons to emerge in the passing game, the Giants have a chance to make the Panthers one-dimensional if Jenkins can shut down Funchess coming off a strong outing against the Saints’ Michael Thomas. Funchess leads Carolina in receiving with 185 yards and one touchdown. Injury Report

Giants: OUT: TE Evan Engram (knee), LB Olivier Vernon (ankle).

Panthers: OUT: TE Greg Olsen (foot). QUESTIONABLE: LB Jared Norris (toe). Giant Facts: With 100 yards from scrimmage Sunday, Saquon Barkley would become only the third player in NFL history (Kareem Hunt, Adrian Peterson) to do so in each of his first five career games. … Since the beginning of last season, the Giants are allowing a league-high 5.84 yards per catch after a reception. … New York is tied with Minnesota for the fourth-best red zone defense. Opponents have scored a touchdown on only 37.5 percent of redzone possessions.

The Prediction: Panthers 27, Giants 23.