GIANTS GAMEDAY

The Game: Giants (5-9) at Colts (8-6), Lucas Oil Stadium, Sunday 1:00 p.m. ET (CBS)

The Line: Indianapolis by 10.5 History: The Colts lead the all-time series, 11-7. Indianapolis has won the last three matchups including a 40-24 romp in 2014 at MetLife Stadium. New York hasn’t won since 2002.

Key Matchups

Giants RB Saquon Barkley vs. Colts LB Darius Leonard: Barkley has at least 100 yards from scrimmage in six of the last seven games. Indianapolis’ rookie outside linebacker leads the NFL with 146 tackles.

Giants WR Cody Latimer vs. Colts CBs: Latimer came off injured reserve this week and hasn’t played since Week 4. With two receivers out, expect him to play a significant number of snaps against Indianapolis’ 15th-ranked pass defense.

Giants CB Janoris Jenkins vs. Colts WR T.Y. Hilton: The Giants’ veteran corner has been one of the league’s best in the second half of the season, according to Pro Football Focus metrics. Jenkins has one of his toughest matchups in Hilton, who last week solidified his fifth 1,000-yard campaign in the last six seasons.

Giants LB B.J. Goodson vs. Colts TE Eric Ebron: Goodson will take on a larger role this week with defensive captain Alec Ogletree out. He had a team-high 10 tackles against the Titans and at times will have to cover Ebron, who leads all NFL tight ends with 12 touchdowns.

Injury Report:

Giants: OUT: WR Odell Beckham Jr. (quad), LB Alec Ogletree (concussion), C Spencer Pulley (calf), WR Russell Shepard (ankle). QUESTIONABLE: DL Kerry Wynn (thumb).

Colts: OUT: S Clayton Geathers (knee). QUESTIONABLE: LB Anthony Walker (shoulder), G Mark Glowinski (ankle), WR T.Y. Hilton (ankle), S George Odom (knee), S Mike Mitchell (calf).

Giant Facts: Since the start of last season, the Giants are averaging 21.6 points per game when Odell Beckham Jr. plays and 14.8 points when he does not. … Saquon Barkley is seven receptions away from breaking Reggie Bush’s NFL record for a rookie running back of 88 set in 2006. … B.J. Hill is currently the league’s only rookie defensive lineman with at least 45 tackles, six tackles-for-loss and five sacks.

The Prediction: Colts 27, Giants 16.